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USP21 encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. Additionally we are shipping USP21 Antibodies (97) and many more products for this protein.
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USP21 interacts with, deubiquitinates and stabilizes BRCA2 (show BRCA2 Proteins) to promote efficient RAD51 (show RAD51 Proteins) loading at DNA double-strand breaks.
a critical role of p38 (show CRK Proteins)-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (show CRK Proteins)-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
USP21 recruits and stabilises Gli1 (show GLI1 Proteins) at the centrosome.
USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG
Data show that SUMOylated BANP (show BANP Proteins), E5R, and Nac1 (show NACC1 Proteins) (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1 (show NKX2-1 Proteins)-interacting protein 5 (show CAPS Proteins) (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase
The protein stability of IL-33 (show IL33 Proteins) is maintained by USP21 through deubiquitination
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 (show GATA3 Proteins)
Study observed a reduction in the number of A549 cells developing a primary cilium upon serum starvation when USP21 was depleted with two independent siRNA oligos.
Study report that USP21 cleaves Ub polymers, and with reduced activity also targets ISG15 (show ISG15 Proteins), but is inactive against NEDD8 (show NEDD8 Proteins).
USP21 plays an important role in the down-regulation of TNFalpha (show TNF Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation through deubiquitinating RIP1 (show UQCRFS1 Proteins).
Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation
Overexpression of USP21 inhibited RNA virus-induced RIG-I (show DDX58 Proteins) polyubiquitination and RIG-I (show DDX58 Proteins)-mediated interferon (show IFNA Proteins) signaling, while USP21 deletion resulted in elevated RIG-I (show DDX58 Proteins) polyubiquitination, IRF3 (show IRF3 Proteins) phosphorylation, IFN production, and antiviral responses.
USP21 plays an important role in the down-regulation of TNFalpha (show TNF Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation through deubiquitinating RIP1 (show RALBP1 Proteins).
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described.
ubiquitin specific peptidase 21
, Ubiquitin specific peptidase 21
, NEDD8-specific protease
, deubiquitinating enzyme 21
, ubiquitin carboxyl-terminal hydrolase 21
, ubiquitin specific protease 21
, ubiquitin thioesterase 21
, ubiquitin thiolesterase 21
, ubiquitin-specific processing protease 21
, ubiquitin-specific protease 16
, ubiquitin-specific-processing protease 21
, ubiquitin specific protease 23
, ubiquitin-specific protease 21