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Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Additionally we are shipping USP22 Proteins (3) and many more products for this protein.
Showing 10 out of 87 products:
Human Monoclonal USP22 Primary Antibody for WB - ABIN1882289
Bechtel, Rosenfelder, Duda, Schmidt, Ernst, Wellenreuther, Mehrle, Schuster, Bahr, Blöcker, Heubner, Hoerlein, Michel, Wedler, Köhrer, Ottenwälder, Poustka, Wiemann, Schupp: The full-ORF clone resource of the German cDNA Consortium. in BMC genomics 2008
Show all 5 Pubmed References
Human Polyclonal USP22 Primary Antibody for IHC (p), SimWes - ABIN4364565
Schrecengost, Dean, Goodwin, Schiewer, Urban, Stanek, Sussman, Hicks, Birbe, Draganova-Tacheva, Visakorpi, DeMarzo, McMahon, Knudsen: USP22 regulates oncogenic signaling pathways to drive lethal cancer progression. in Cancer research 2014
Show all 2 Pubmed References
Human Polyclonal USP22 Primary Antibody for WB - ABIN388913
Hong, Lee, Chung: Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination. in Journal of cellular physiology 2015
Human Polyclonal USP22 Primary Antibody for IHC (p), WB - ABIN388914
Wang, Zhu, Guo, Wang, Yang: Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma. in Human pathology 2015
Loss of Ataxin-7 (show ATXN7 Antibodies) results in a toxic gain of activity of the Non-stop deubiquitinase.
Data establish that Nonstop actually functions as an ubiquitin (show UBA52 Antibodies) protease to control the levels of ubiquitinated histone H2B in flies. We further establish that Nonstop is the functional homolog of yeast Ubp8
3 additional subunits of TFTC/STAGA (dSgf11, non-stop, & en(y)2) help form the deubiquitination module. This module is an enhancer of position effect variegation in Drosophila.
In breast cancer cell lines USP22 increases c-Myc (show MYC Antibodies) stability through c-Myc (show MYC Antibodies) deubiquitination, which is closely correlated with breast cancer progression.
that nuclear GSK3beta (show GSK3b Antibodies)- and USP22-mediated KDM1A (show KDM1A Antibodies) stabilization is essential for glioblastoma tumorigenesis
findings suggest that USP22 may be involved in hepatocellular carcinoma progression in cooperation with survivin (show BIRC5 Antibodies).
These findings provide evidence that high USP22 expression might be important in tumor progression and serves as an independent molecular marker for poor hepatocellular carcinoma prognosis
USP22 attenuated the invasion capacity of colon cancer cells by inhibiting the STAT3 (show STAT3 Antibodies)/MMP9 (show MMP9 Antibodies) signaling pathway.
Our data indicated that USP22 may promote lung adenocarcinoma cell invasion by the induction of EMT (show ITK Antibodies).
Data show that the aggregates formed by polyQ-expanded ataxin 7 (show ATXN7 Antibodies) sequester ubiquitin-specific protease (USP22) through specific interactions.
the deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth, and it promotes cell proliferation via the c-Myc (show MYC Antibodies)/cyclin D2 (show CCND2 Antibodies), BMI-1 (show BMI1 Antibodies) and p53 (show TP53 Antibodies) pathways in HeLa cells
ShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt (show AKT1 Antibodies) pathway in nasopharyngeal carcinoma.
Data indicate that ubiquitin specific peptidase 22 (USP22)-mediated sirtuin 1 (SIRT1 (show SIRT1 Antibodies)) deubiquitination inhibits STAT3 (show STAT3 Antibodies) transcription factor acetylation and its transcriptional activation.
high D-glucose induces increased expression of USP22 in cultured podocytes and diabetic rats. USP22 inhibition confers a protective effect against high glucose-induced podocyte depletion, apoptosis and inflammation.
Usp22 deficiency impairs intestinal epithelial lineage specification.
USP22 is a transcriptional repressor of the locus encoding the core pluripotency factor sex-determining region Y-box 2 (SOX2 (show SOX2 Antibodies)) in embryonic stem cells.
Genetic deletion of the usp22 gene results in Sirt1 (show SIRT1 Antibodies) instability, elevated p53 (show TP53 Antibodies) transcriptional activity and early embryonic lethality.
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).
ubiquitin specific peptidase 22
, ubiquitin thiolesterase 22
, ubiquitin carboxyl-terminal hydrolase 22-like
, ubiquitin specific protease 22
, universal stress protein
, deubiquitinating enzyme 22
, ubiquitin carboxyl-terminal hydrolase 22
, ubiquitin thioesterase 22
, ubiquitin-specific processing protease 22
, ubiquitin-specific-processing protease 22