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Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Additionally we are shipping USP22 Antibodies (87) and USP22 Proteins (3) and many more products for this protein.
Loss of Ataxin-7 (show ATXN7 ELISA Kits) results in a toxic gain of activity of the Non-stop deubiquitinase.
Data establish that Nonstop actually functions as an ubiquitin (show UBA52 ELISA Kits) protease to control the levels of ubiquitinated histone H2B in flies. We further establish that Nonstop is the functional homolog of yeast Ubp8
3 additional subunits of TFTC/STAGA (dSgf11, non-stop, & en(y)2) help form the deubiquitination module. This module is an enhancer of position effect variegation in Drosophila.
we demonstrated that USP22 was highly expressed in OS tissues and cells lines. Downregulation of USP22 inhibited OS cell proliferation, invasion, and EMT (show ITK ELISA Kits) in vitro. In addition, downregulation of USP22 suppressed OS tumor growth and metastasis in vivo.
In breast cancer cell lines USP22 increases c-Myc (show MYC ELISA Kits) stability through c-Myc (show MYC ELISA Kits) deubiquitination, which is closely correlated with breast cancer progression.
that nuclear GSK3beta (show GSK3b ELISA Kits)- and USP22-mediated KDM1A (show KDM1A ELISA Kits) stabilization is essential for glioblastoma tumorigenesis
findings suggest that USP22 may be involved in hepatocellular carcinoma progression in cooperation with survivin (show BIRC5 ELISA Kits).
These findings provide evidence that high USP22 expression might be important in tumor progression and serves as an independent molecular marker for poor hepatocellular carcinoma prognosis
USP22 attenuated the invasion capacity of colon cancer cells by inhibiting the STAT3 (show STAT3 ELISA Kits)/MMP9 (show MMP9 ELISA Kits) signaling pathway.
Our data indicated that USP22 may promote lung adenocarcinoma cell invasion by the induction of EMT (show ITK ELISA Kits).
Data show that the aggregates formed by polyQ-expanded ataxin 7 (show ATXN7 ELISA Kits) sequester ubiquitin-specific protease (USP22) through specific interactions.
the deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth, and it promotes cell proliferation via the c-Myc (show MYC ELISA Kits)/cyclin D2 (show CCND2 ELISA Kits), BMI-1 (show BMI1 ELISA Kits) and p53 (show TP53 ELISA Kits) pathways in HeLa cells
ShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt (show AKT1 ELISA Kits) pathway in nasopharyngeal carcinoma.
high D-glucose induces increased expression of USP22 in cultured podocytes and diabetic rats. USP22 inhibition confers a protective effect against high glucose-induced podocyte depletion, apoptosis and inflammation.
Usp22 deficiency impairs intestinal epithelial lineage specification.
USP22 is a transcriptional repressor of the locus encoding the core pluripotency factor sex-determining region Y-box 2 (SOX2 (show SOX2 ELISA Kits)) in embryonic stem cells.
Genetic deletion of the usp22 gene results in Sirt1 (show SIRT1 ELISA Kits) instability, elevated p53 (show TP53 ELISA Kits) transcriptional activity and early embryonic lethality.
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).
ubiquitin specific peptidase 22
, ubiquitin thiolesterase 22
, ubiquitin carboxyl-terminal hydrolase 22-like
, ubiquitin specific protease 22
, universal stress protein
, deubiquitinating enzyme 22
, ubiquitin carboxyl-terminal hydrolase 22
, ubiquitin thioesterase 22
, ubiquitin-specific processing protease 22
, ubiquitin-specific-processing protease 22