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Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. Additionally we are shipping and many more products for this protein.
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Human Polyclonal USP24 Primary Antibody for IP, WB - ABIN251514
Zhang, Lubin, Chen, Sun, Gong: The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability. in Cell cycle (Georgetown, Tex.) 2012
USP24 level was decreased during the early stage of cancer and the mitotic stage of the cell cycle to regulate its substrates p300 (show EP300 Antibodies), Bax (show BAX Antibodies), E2F4 (show E2F4 Antibodies) and securin (show PTTG1 Antibodies), resulting in decreased cell apoptosis and increased cell cycle progression and, thus, cancer formation.
Data show that ubiquitin-specific peptidase 24 (USP24) is highly expressed in cell lines with enhanced malignancy and in late-stage lung cancer clinical samples.
USP24 deubiquitinase regulates the DNA damage response by directly targeting the p53 tumor suppressor (show TP53 Antibodies).
the novel compound EOAI3402143 dose-dependently inhibited Usp9x (show USP9X Antibodies) and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice.
These results suggested that USP24 expression is tightly regulated at its transcription level and NFkappaB plays an important role in this process.
The knockdown of USP24 in two human cell lines decreased the steady-state levels of DDB2 (show DDB2 Antibodies), indicating that USP24-mediated DDB2 (show DDB2 Antibodies) deubiquitination prevents DDB2 (show DDB2 Antibodies) degradation.
The present study is the first to report a lack of association between SNPs of USP24 and parkinson disease in Han Chinese patients. Other
USP24 alone plays a role in PD susceptibility among Taiwanese people >or=60 years of age, or acting synergistically with USP40 (show USP40 Antibodies) and UCHL1 (show UCHL1 Antibodies) in the total subjects.
Data suggest that genetic variants in USP24 affect the risk for late-onset Parkinson disease (PD), which is consistent with the predicted role of the ubiquitination pathway in PD etiology.
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004
ubiquitin specific protease 24
, ubiquitin carboxyl-terminal hydrolase 24
, ubiquitin specific peptidase 24
, novel protein similar to vertebrate ubiquitin specific protease
, ubiquitin carboxyl-terminal hydrolase 24-like
, deubiquitinating enzyme 24
, ubiquitin thioesterase 24
, ubiquitin thiolesterase 24
, ubiquitin-specific processing protease 24
, ubiquitin-specific-processing protease 24