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Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Additionally we are shipping Ubiquitin Specific Peptidase 3 Proteins (4) and many more products for this protein.
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Human Monoclonal USP3 Primary Antibody for IF, ELISA - ABIN564284
Mosbech, Lukas, Bekker-Jensen, Mailand: The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases. in The Journal of biological chemistry 2013
Depletion of USP3 lead to accelerated degradation of p53 (show TP53 Antibodies) in normal cells thereby enhanced cell proliferation and transformation. Reconstitution of wildtype USP3, but not the USP3 C168S mutant, restored the stability of p53 (show TP53 Antibodies) protein and inhibited cell proliferation and transformation.
Taken together, the results suggested that USP3 is a negative regulator of ubiquitination signaling, counteracting RNF168 (show RNF168 Antibodies)- and RNF8 (show RNF8 Antibodies)-mediated ubiquitination.
the role of UCP3 (show UCP3 Antibodies) gene in functional status and survival at old age.
Ubiquitin-specific protease 3 (USP3) is a deubiquitinating enzyme for monoubiquitinated histones H2A and H2B; USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo.
USP3 deletion increased the levels of histone ubiquitination in adult tissues, reduced the hematopoietic stem cell reserves over time, and shortened animal life span.
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (By similarity).
ubiquitin specific peptidase 3
, ubiquitin specific protease 3
, ubiquitin carboxyl-terminal hydrolase 3-like
, deubiquitinating enzyme 3
, ubiquitin carboxyl-terminal hydrolase 3
, ubiquitin thioesterase 3
, ubiquitin thiolesterase 3
, ubiquitin-specific-processing protease 3