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USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008].. Additionally we are shipping Usp30 Proteins (7) and many more products for this protein.
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Human Polyclonal Usp30 Primary Antibody for IHC, IHC (p) - ABIN4364579
Bingol, Tea, Phu, Reichelt, Bakalarski, Song, Foreman, Kirkpatrick, Sheng: The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. in Nature 2014
show that USP30 delays mitophagy by delaying PARK2 (show PARK2 Antibodies) recruitment to the mitochondria during mitophagy
These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy.
The mechanism by which parkin (show PARK2 Antibodies), an E3 ubiquitin ligase (show MUL1 Antibodies), and USP30, a mitochondrion-localized deubiquitylase, regulate mitophagy, was investigated.
reducing USP30 activity enhances mitochondrial degradation in neurons
USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination.
USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008
ubiquitin specific peptidase 30
, ubiquitin specific protease 30
, ubiquitin carboxyl-terminal hydrolase 30
, Ub-specific protease 30
, Ubiquitin thioesterase 30
, Deubiquitinating enzyme 30
, Ubiquitin-specific protease 30
, ubiquitin-specific-processing protease 30
, ubiquitin carboxyl-terminal hydrolase 30-like
, deubiquitinating enzyme 30
, ub-specific protease 30
, ubiquitin thioesterase 30
, ubiquitin thiolesterase 30
, ubiquitin-specific protease 30