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Ubiquitin Specific Peptidase 37 Proteins (USP37)

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Additionally we are shipping USP37 Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP37 57695 Q86T82
Mouse USP37 USP37 319651 Q8C0R0
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Top USP37 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

USP37 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Ubiquitin Specific Peptidase 37 (USP37) Interaction Partners

Human Ubiquitin Specific Peptidase 37 (USP37) interaction partners

  1. USP37 associates with cohesin and contributes to sister chromatid resolution. Cohesion defects are rescued by expression of an RNAi-resistant USP37, but not the catalytically impaired USP37(C350A) mutant.

  2. USP37 is significantly upregulated in human lung cancer tissues, where its expression is positively correlated with c-Myc (show MYC Proteins) protein expression.

  3. These results suggested that the UIMs in USP37 contribute to the full enzymatic activity, but not ubiquitin chain substrate specificity, of USP37 possibly by holding the ubiquitin chain substrate in the proximity of the catalytic core.

  4. our findings of USP37-modulating PLZF (show ZBTB16 Proteins)/RARA (show RARA Proteins) stability and cell transformation suggest that USP37 is a potential therapeutic target for PLZF (show ZBTB16 Proteins)/RARA (show RARA Proteins)-associated APL (show FASL Proteins)

  5. USP37 links REST to the control of p27 (show PAK2 Proteins) stability and cell proliferation.

  6. Skp1 (show SKP1 Proteins)-Cul1 (show CUL1 Proteins)-F-box ubiquitin ligase (SCF (show KITLG Proteins)(betaTrCP (show BTRC Proteins)))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry

  7. The deubiquitinase USP37 binds CDH1 (show CDH1 Proteins) and removes degradative polyubiquitin (show UBB Proteins) from cyclin A (show CCNA2 Proteins). USP37 was induced by E2F (show E2F1 Proteins) factors in G1, peaked at G1/S, and was degraded in late mitosis. Phosphorylation of USP37 by CDK2 (show CDK2 Proteins) stimulated its full activity.

USP37 Protein Profile

Protein Summary

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-630 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (By similarity).

Gene names and symbols associated with USP37

  • ubiquitin specific peptidase 37 (USP37)
  • ubiquitin specific peptidase 37 (usp37)
  • ubiquitin specific peptidase 37 (LOC100347231)
  • ubiquitin specific peptidase 37 (Usp37)
  • 4932415L06Rik protein
  • C330008N13Rik protein
  • wu:fi15b04 protein
  • wu:fi38d03 protein
  • zgc:152882 protein
  • zgc:153999 protein

Protein level used designations for USP37

ubiquitin specific peptidase 37 , ubiquitin specific protease 37 , ubiquitin carboxyl-terminal hydrolase 37-like , deubiquitinating enzyme 37 , tmp_locus_50 , ubiquitin carboxyl-terminal hydrolase 37 , ubiquitin thioesterase 37 , ubiquitin thiolesterase 37 , ubiquitin-specific-processing protease 37 , Deubiquitinating enzyme 37 , Ubiquitin carboxyl-terminal hydrolase 37 , Ubiquitin thiolesterase 37 , Ubiquitin-specific-processing protease 37 , fi15b04 , usp39

GENE ID SPECIES
459944 Pan troglodytes
701732 Macaca mulatta
100124313 Xenopus (Silurana) tropicalis
100155158 Sus scrofa
100347231 Oryctolagus cuniculus
100389662 Callithrix jacchus
100481404 Ailuropoda melanoleuca
100541053 Meleagris gallopavo
100602108 Nomascus leucogenys
57695 Homo sapiens
319651 Mus musculus
407168 Bos taurus
488523 Canis lupus familiaris
424216 Gallus gallus
768201 Danio rerio
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