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The protein encoded by USP4 is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. Additionally we are shipping USP4 Proteins (4) and many more products for this protein.
Showing 10 out of 102 products:
Human Polyclonal USP4 Primary Antibody for EIA, WB - ABIN955490
Zhao, Schlesiger, Masucci, Lindsten: The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway. in Journal of cellular and molecular medicine 2010
Show all 5 references for ABIN955490
Human Polyclonal USP4 Primary Antibody for IHC (p), WB - ABIN658704
Morgan, Han, Lam, Fraser, Ferguson: Association analysis of 3p21 with Crohn's disease in a New Zealand population. in Human immunology 2010
Show all 2 references for ABIN658704
Human Polyclonal USP4 Primary Antibody for EIA, IHC (p) - ABIN357526
Laurell, Velázquez-Fernández, Lindsten, Juhlin, Enberg, Geli, Höög, Kjellman, Lundeberg, Hamberger, Larsson, Nilsson, Bäckdahl: Transcriptional profiling enables molecular classification of adrenocortical tumours. in European journal of endocrinology / European Federation of Endocrine Societies 2009
Human Polyclonal USP4 Primary Antibody for ELISA, WB - ABIN185005
Frederick, Rolfe, Chiu: The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines. in Oncogene 1998
USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.
USP4 cooperates with CtIP (show RBBP8 Antibodies) in DNA double-strand break end resection.
Results demonstrate that aberrant expression of USP4 contributes to the development and progression of colorectal cancer and reveal a critical mechanism underlying USP4-mediated oncogenic activity.
findings thus identify USP4 as a novel DNA repair regulator and invoke a model in which ubiquitin adducts regulate USP enzyme interactions and functions.
USP4 requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover by promoting ubiquitin exchange.
USP4 and IL-17 (show IL17A Antibodies) mRNA, but not RORgammat mRNA, were significantly elevated in CD4 (show CD4 Antibodies)(+) T cells from patients with rheumatic heart disease
USP4 overexpression is associated with hepatocellular carcinoma.
Authors identified USP4 as a new positive regulator for RIG-I (show DDX58 Antibodies) that acts through deubiquitinating K48-linked ubiquitin chains and stabilizing RIG-I (show DDX58 Antibodies).
Data suggest that USP4 down-regulates RIP1 (show UQCRFS1 Antibodies) (receptor-interacting serine-threonine kinase (show TLK2 Antibodies) 1)-mediated TNFalpha (tumor necrosis factor-alpha (show TNF Antibodies)) activation and promotes TNFalpha (show TNF Antibodies)-induced apoptosis via deubiquitination of RIP1 (show UQCRFS1 Antibodies) in head/neck carcinoma.
the interaction with USP4 may regulate the structure and function of the proteasome or the turnover of specific proteasomal substrates.
USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response
Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta (show TGFB1 Antibodies) type I receptor (show TGFBR1 Antibodies) and AKT (show AKT1 Antibodies) signalling pathways.
USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 (show TP53 Antibodies) levels.
the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties.
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.
ubiquitin specific protease 4
, deubiquitinating enzyme 4
, ubiquitin carboxyl-terminal esterase 4
, ubiquitin carboxyl-terminal hydrolase 4
, ubiquitin specific protease 4 (proto-oncogene)
, ubiquitin thioesterase 4
, ubiquitin thiolesterase 4
, ubiquitin-specific processing protease 4
, ubiquitous nuclear protein homolog
, ubiquitin-specific-processing protease 4
, ubiquitous nuclear protein