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Ubiquitin Specific Peptidase 4 (USP4) ELISA Kits

The protein encoded by USP4 is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. Additionally we are shipping USP4 Antibodies (110) and USP4 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human USP4 USP4 7375 Q13107
Anti-Mouse USP4 USP4 22258 P35123
Anti-Rat USP4 USP4 290864 B2GUZ1
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More ELISA Kits for USP4 Interaction Partners

Human Ubiquitin Specific Peptidase 4 (USP4) interaction partners

  1. Ubiquitin-specific protease 4 (USP4), recently identified as a beta (show SUCLA2 ELISA Kits)-catenin (show CTNNB1 ELISA Kits)-specific deubiquitinylating enzyme, was highly expressed in PC14PE6/LvBr4 cells and involved in the increased stability of beta-catenin (show CTNNB1 ELISA Kits) protein.

  2. USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.

  3. USP4 cooperates with CtIP (show RBBP8 ELISA Kits) in DNA double-strand break end resection.

  4. Results demonstrate that aberrant expression of USP4 contributes to the development and progression of colorectal cancer and reveal a critical mechanism underlying USP4-mediated oncogenic activity.

  5. findings thus identify USP4 as a novel DNA repair regulator and invoke a model in which ubiquitin adducts regulate USP enzyme interactions and functions.

  6. USP4 requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover by promoting ubiquitin exchange.

  7. USP4 and IL-17 (show IL17A ELISA Kits) mRNA, but not RORgammat mRNA, were significantly elevated in CD4 (show CD4 ELISA Kits)(+) T cells from patients with rheumatic heart disease

  8. USP4 overexpression is associated with hepatocellular carcinoma.

  9. Authors identified USP4 as a new positive regulator for RIG-I (show DDX58 ELISA Kits) that acts through deubiquitinating K48-linked ubiquitin chains and stabilizing RIG-I (show DDX58 ELISA Kits).

  10. Data suggest that USP4 down-regulates RIP1 (receptor-interacting serine-threonine kinase (show TLK2 ELISA Kits) 1)-mediated TNFalpha (tumor necrosis factor-alpha (show TNF ELISA Kits)) activation and promotes TNFalpha (show TNF ELISA Kits)-induced apoptosis via deubiquitination of RIP1 in head/neck carcinoma.

Mouse (Murine) Ubiquitin Specific Peptidase 4 (USP4) interaction partners

  1. USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response

  2. Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta (show TGFB1 ELISA Kits) type I receptor (show TGFBR1 ELISA Kits) and AKT (show AKT1 ELISA Kits) signalling pathways.

  3. USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 (show TP53 ELISA Kits) levels.

  4. the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties.

USP4 Antigen Profile

Antigen Summary

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with USP4

  • ubiquitin specific protease 4 (LOC100228772) antibody
  • ubiquitin specific peptidase 4 (proto-oncogene) (USP4) antibody
  • ubiquitin specific peptidase 4 (proto-oncogene) (Usp4) antibody
  • F730026I20Rik antibody
  • mKIAA4155 antibody
  • Unp antibody
  • Unph antibody

Protein level used designations for USP4

ubiquitin specific protease 4 , deubiquitinating enzyme 4 , ubiquitin carboxyl-terminal esterase 4 , ubiquitin carboxyl-terminal hydrolase 4 , ubiquitin specific protease 4 (proto-oncogene) , ubiquitin thioesterase 4 , ubiquitin thiolesterase 4 , ubiquitin-specific processing protease 4 , ubiquitous nuclear protein homolog , ubiquitin-specific-processing protease 4 , ubiquitous nuclear protein

100228772 Taeniopygia guttata
7375 Homo sapiens
22258 Mus musculus
290864 Rattus norvegicus
508042 Bos taurus
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