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Ubiquitin Specific Peptidase 4 Proteins (USP4)

The protein encoded by USP4 is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. Additionally we are shipping USP4 Antibodies (102) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP4 7375 Q13107
Mouse USP4 USP4 22258 P35123
Rat USP4 USP4 290864 B2GUZ1
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Top USP4 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

USP4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Top referenced USP4 Proteins

  1. Human USP4 Protein expressed in Wheat germ - ABIN1324801 : Zhang, Berger, Yang, Lu: USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. in The EMBO journal 2011 (PubMed)

More Proteins for Ubiquitin Specific Peptidase 4 (USP4) Interaction Partners

Human Ubiquitin Specific Peptidase 4 (USP4) interaction partners

  1. USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.

  2. USP4 cooperates with CtIP (show RBBP8 Proteins) in DNA double-strand break end resection.

  3. Results demonstrate that aberrant expression of USP4 contributes to the development and progression of colorectal cancer and reveal a critical mechanism underlying USP4-mediated oncogenic activity.

  4. findings thus identify USP4 as a novel DNA repair regulator and invoke a model in which ubiquitin adducts regulate USP enzyme interactions and functions.

  5. USP4 requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover by promoting ubiquitin exchange.

  6. USP4 and IL-17 (show IL17A Proteins) mRNA, but not RORgammat mRNA, were significantly elevated in CD4 (show CD4 Proteins)(+) T cells from patients with rheumatic heart disease

  7. USP4 overexpression is associated with hepatocellular carcinoma.

  8. Authors identified USP4 as a new positive regulator for RIG-I (show DDX58 Proteins) that acts through deubiquitinating K48-linked ubiquitin chains and stabilizing RIG-I (show DDX58 Proteins).

  9. Data suggest that USP4 down-regulates RIP1 (show UQCRFS1 Proteins) (receptor-interacting serine-threonine kinase (show TLK2 Proteins) 1)-mediated TNFalpha (tumor necrosis factor-alpha (show TNF Proteins)) activation and promotes TNFalpha (show TNF Proteins)-induced apoptosis via deubiquitination of RIP1 (show UQCRFS1 Proteins) in head/neck carcinoma.

  10. the interaction with USP4 may regulate the structure and function of the proteasome or the turnover of specific proteasomal substrates.

Mouse (Murine) Ubiquitin Specific Peptidase 4 (USP4) interaction partners

  1. USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response

  2. Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta (show TGFB1 Proteins) type I receptor (show TGFBR1 Proteins) and AKT (show AKT1 Proteins) signalling pathways.

  3. USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 (show TP53 Proteins) levels.

  4. the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties.

USP4 Protein Profile

Protein Summary

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with USP4

  • ubiquitin specific protease 4 (LOC100228772)
  • ubiquitin specific peptidase 4 (proto-oncogene) (USP4)
  • ubiquitin specific peptidase 4 (proto-oncogene) (Usp4)
  • F730026I20Rik protein
  • mKIAA4155 protein
  • Unp protein
  • Unph protein

Protein level used designations for USP4

ubiquitin specific protease 4 , deubiquitinating enzyme 4 , ubiquitin carboxyl-terminal esterase 4 , ubiquitin carboxyl-terminal hydrolase 4 , ubiquitin specific protease 4 (proto-oncogene) , ubiquitin thioesterase 4 , ubiquitin thiolesterase 4 , ubiquitin-specific processing protease 4 , ubiquitous nuclear protein homolog , ubiquitin-specific-processing protease 4 , ubiquitous nuclear protein

100228772 Taeniopygia guttata
7375 Homo sapiens
22258 Mus musculus
290864 Rattus norvegicus
508042 Bos taurus
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