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The protein encoded by USP4 is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. Additionally we are shipping USP4 Antibodies (111) and USP4 Proteins (4) and many more products for this protein.
Data suggest that ubiquitin specific protease 4 (USP4) interacts with interferon regulatory factor 8 (IRF8 (show IRF8 ELISA Kits)) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 (show IRF8 ELISA Kits) protein levels in regulatory T-lymphocytes; USP4 and IRF8 (show IRF8 ELISA Kits) are also expressed in helper T-lymphocytes.
USP4 inhibits p53 (show TP53 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) through deubiquitinating and stabilizing HDAC2 (show HDAC2 ELISA Kits)
ubiquitin-specific protease 4 (USP4) is a binding partner of RNPS1 (show RNPS1 ELISA Kits).
Data indicate that programmed cell death 4 (PDCD4 (show PDCD4 ELISA Kits)) was identified to be a target of ubiquitin-specific protease 4 (USP4), which plays a role as a tumor suppressor.
Ubiquitin-specific protease 4 (USP4), recently identified as a beta (show SUCLA2 ELISA Kits)-catenin (show CTNNB1 ELISA Kits)-specific deubiquitinylating enzyme, was highly expressed in PC14PE6/LvBr4 cells and involved in the increased stability of beta-catenin (show CTNNB1 ELISA Kits) protein.
USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.
USP4 cooperates with CtIP (show RBBP8 ELISA Kits) in DNA double-strand break end resection.
Results demonstrate that aberrant expression of USP4 contributes to the development and progression of colorectal cancer and reveal a critical mechanism underlying USP4-mediated oncogenic activity.
findings thus identify USP4 as a novel DNA repair regulator and invoke a model in which ubiquitin adducts regulate USP enzyme interactions and functions.
USP4 requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover by promoting ubiquitin exchange.
The authors demonstrated that ubiquitin-specific protease (USP) 4 strongly induces activin (show Actbeta ELISA Kits)/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (show SMAD4 ELISA Kits).
USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response
Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta (show TGFB1 ELISA Kits) type I receptor (show TGFBR1 ELISA Kits) and AKT (show AKT1 ELISA Kits) signalling pathways.
USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 (show TP53 ELISA Kits) levels.
the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties.
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.
ubiquitin specific protease 4
, deubiquitinating enzyme 4
, ubiquitin carboxyl-terminal esterase 4
, ubiquitin carboxyl-terminal hydrolase 4
, ubiquitin specific protease 4 (proto-oncogene)
, ubiquitin thioesterase 4
, ubiquitin thiolesterase 4
, ubiquitin-specific processing protease 4
, ubiquitous nuclear protein homolog
, ubiquitin-specific-processing protease 4
, ubiquitous nuclear protein