Ubiquitin Specific Peptidase 4 Proteins (USP4)

The protein encoded by USP4 is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. Additionally we are shipping USP4 Antibodies (111) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP4 7375 Q13107
Mouse USP4 USP4 22258 P35123
Rat USP4 USP4 290864 B2GUZ1
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Top USP4 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

USP4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

Top referenced USP4 Proteins

  1. Human USP4 Protein expressed in Wheat germ - ABIN1324801 : Zhang, Berger, Yang, Lu: USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. in The EMBO journal 2011 (PubMed)

More Proteins for Ubiquitin Specific Peptidase 4 (USP4) Interaction Partners

Human Ubiquitin Specific Peptidase 4 (USP4) interaction partners

  1. Data suggest that ubiquitin specific protease 4 (USP4) interacts with interferon regulatory factor 8 (IRF8 (show IRF8 Proteins)) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 (show IRF8 Proteins) protein levels in regulatory T-lymphocytes; USP4 and IRF8 (show IRF8 Proteins) are also expressed in helper T-lymphocytes.

  2. USP4 inhibits p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) through deubiquitinating and stabilizing HDAC2 (show HDAC2 Proteins)

  3. ubiquitin-specific protease 4 (USP4) is a binding partner of RNPS1 (show RNPS1 Proteins).

  4. Data indicate that programmed cell death 4 (PDCD4 (show PDCD4 Proteins)) was identified to be a target of ubiquitin-specific protease 4 (USP4), which plays a role as a tumor suppressor.

  5. Ubiquitin-specific protease 4 (USP4), recently identified as a beta (show SUCLA2 Proteins)-catenin (show CTNNB1 Proteins)-specific deubiquitinylating enzyme, was highly expressed in PC14PE6/LvBr4 cells and involved in the increased stability of beta-catenin (show CTNNB1 Proteins) protein.

  6. USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.

  7. USP4 cooperates with CtIP (show RBBP8 Proteins) in DNA double-strand break end resection.

  8. Results demonstrate that aberrant expression of USP4 contributes to the development and progression of colorectal cancer and reveal a critical mechanism underlying USP4-mediated oncogenic activity.

  9. findings thus identify USP4 as a novel DNA repair regulator and invoke a model in which ubiquitin adducts regulate USP enzyme interactions and functions.

  10. USP4 requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover by promoting ubiquitin exchange.

Mouse (Murine) Ubiquitin Specific Peptidase 4 (USP4) interaction partners

  1. The authors demonstrated that ubiquitin-specific protease (USP) 4 strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (show SMAD4 Proteins).

  2. USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response

  3. Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta (show TGFB1 Proteins) type I receptor (show TGFBR1 Proteins) and AKT (show AKT1 Proteins) signalling pathways.

  4. USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 (show TP53 Proteins) levels.

  5. the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties.

USP4 Protein Profile

Protein Summary

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with USP4

  • ubiquitin specific protease 4 (LOC100228772)
  • ubiquitin specific peptidase 4 (proto-oncogene) (USP4)
  • ubiquitin specific peptidase 4 (proto-oncogene) (Usp4)
  • F730026I20Rik protein
  • mKIAA4155 protein
  • Unp protein
  • Unph protein

Protein level used designations for USP4

ubiquitin specific protease 4 , deubiquitinating enzyme 4 , ubiquitin carboxyl-terminal esterase 4 , ubiquitin carboxyl-terminal hydrolase 4 , ubiquitin specific protease 4 (proto-oncogene) , ubiquitin thioesterase 4 , ubiquitin thiolesterase 4 , ubiquitin-specific processing protease 4 , ubiquitous nuclear protein homolog , ubiquitin-specific-processing protease 4 , ubiquitous nuclear protein

GENE ID SPECIES
100228772 Taeniopygia guttata
7375 Homo sapiens
22258 Mus musculus
290864 Rattus norvegicus
508042 Bos taurus
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