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Ubiquitin Specific Peptidase 5 Proteins (USP5)

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. Additionally we are shipping USP5 Antibodies (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP5 8078 P45974
Mouse USP5 USP5 22225 P56399
Rat USP5 USP5 297593  
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Top USP5 Proteins at antibodies-online.com

Showing 8 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
$173.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   25 μg Log in to see 2 to 3 Days
$241.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   25 μg Log in to see 5 to 8 Days
$258.30
Details
Rabbit Rabbit Un-conjugated   10 μg Log in to see 5 to 8 Days
$258.30
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   25 μg Log in to see 3 to 4 Days
$413.21
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

USP5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,

Top referenced USP5 Proteins

  1. Human USP5 Protein expressed in Baculovirus infected Insect Cells - ABIN2005325 : Reyes-Turcu, Horton, Mullally, Heroux, Cheng, Wilkinson: The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. in Cell 2006 (PubMed)
    Show all 4 references for ABIN2005325

More Proteins for Ubiquitin Specific Peptidase 5 (USP5) Interaction Partners

Human Ubiquitin Specific Peptidase 5 (USP5) interaction partners

  1. A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 (show UBA1 Proteins) and USP5 enzymes.

  2. Used IM-MS analysis to study conformational flexibility of the multidomain deubiquitinating enzyme ubiquitin specific protease 5 (USP5).

  3. Charge-state distribution and ion mobility analysis revealed that both mono- and tetra-ubiquitin bound to the compact conformation of USP5 only.

  4. Cellular isopeptidase T deubiquitinating enzyme disassembles free ubiquitin chains to facilitate KSHV K7 degradation.

  5. polyubiquitin (show UBB Proteins) chains by USP5 at sites of damage is important for efficient DSB repair

  6. Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome (show Psmd4 Proteins) in vascular smooth muscle cells.

  7. Production of the USP5 isoform 2 was strongly correlated with PTBP1 (show PTBP1 Proteins) expression in glioblastoma tumor samples and cell lines.

  8. USP5 uses multiple zinc fluoride (ZnF)-ubiquitin binding protein (UBP (show SGTA Proteins)) domains for substrate targeting and core catalytic function.

  9. Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain (show PSMA5 Proteins) and isopeptidase T in fetal Down syndrome.

  10. We report the crystal structures of the zinc-finger ubiquitin binding domain (ZnF UBP (show SGTA Proteins)) from the deubiquitinating enzyme isopeptidase T (IsoT, or USP5) alone and in complex with ubiquitin. This domain is required for optimal catalytic activation of IsoT.

Mouse (Murine) Ubiquitin Specific Peptidase 5 (USP5) interaction partners

  1. Suramin and Cav3.2 (show CACNA1H Proteins)/USP5 Tat (show TAT Proteins)-disruptor peptides were also tested in models of diabetic neuropathy and visceral pain, and provided remarkable protection

  2. Knockdown and overexpression studies demonstrated that Usp5 regulates p53 (show TP53 Proteins) (and p73 (show ARHGAP24 Proteins)) levels and alters cell growth and cell cycle distribution associated with p21 induction.

  3. Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome (show Psmd4 Proteins) in vascular smooth muscle cells.

USP5 Protein Profile

Protein Summary

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995

Gene names and symbols associated with USP5

  • ubiquitin specific peptidase 5 (isopeptidase T) (USP5)
  • ubiquitin carboxyl-terminal hydrolase 5 (CNH02890)
  • ubiquitin carboxyl-terminal hydrolase 5 (EHI_049940)
  • ubiquitin carboxyl-terminal hydrolase 5 (CC1G_12961)
  • ubiquitin carboxyl-terminal hydrolase 5 (MCYG_01862)
  • ubiquitin carboxyl-terminal hydrolase 5 (CGB_L3600C)
  • ubiquitin specific protease 5 (PY00546)
  • ubiquitin specific peptidase 5 (LOC100347902)
  • ubiquitin specific peptidase 5 (isopeptidase T) (Usp5)
  • AA407472 protein
  • ISOT protein
  • ISOT-1 protein
  • Ucht protein

Protein level used designations for USP5

ubiquitin carboxyl-terminal hydrolase 5 , Ubiquitin isopeptidase T , ubiquitin specific peptidase 5 (isopeptidase T) isoform 1 , ubiquitin specific peptidase 5 (isopeptidase T) isoform 2 , ubiquitin specific protease 5 , ubiquitin specific peptidase 5 , deubiquitinating enzyme 5 , isopeptidase T , ubiquitin isopeptidase T , ubiquitin specific protease 5 (isopeptidase T) , ubiquitin thioesterase 5 , ubiquitin thiolesterase 5 , ubiquitin-specific protease-5 (ubiquitin isopeptidase T) , ubiquitin-specific-processing protease 5 , ubiquitin carboxy terminal hydrolase T

GENE ID SPECIES
505280 Bos taurus
3259330 Cryptococcus neoformans var. neoformans JEC21
3410770 Entamoeba histolytica HM-1:IMSS
6009870 Coprinopsis cinerea okayama7130
9228979 Arthroderma otae CBS 113480
10185831 Cryptococcus gattii WM276
3790547 Plasmodium yoelii yoelii 17XNL
100347902 Oryctolagus cuniculus
8078 Homo sapiens
22225 Mus musculus
486718 Canis lupus familiaris
297593 Rattus norvegicus
Selected quality suppliers for USP5 Proteins (USP5)
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