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Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. Additionally we are shipping USP5 Antibodies (74) and many more products for this protein.
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study demonstrates that USP5 plays a critical role in tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 (show FOXM1 Proteins) protein, and provides a rationale for USP5 being a potential therapeutic approach against pancreatic ductal adenocarcinoma
Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway.
A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 (show UBA1 Proteins) and USP5 enzymes.
Used IM-MS analysis to study conformational flexibility of the multidomain deubiquitinating enzyme ubiquitin specific protease 5 (USP5).
Charge-state distribution and ion mobility analysis revealed that both mono- and tetra-ubiquitin bound to the compact conformation of USP5 only.
Cellular isopeptidase T deubiquitinating enzyme disassembles free ubiquitin chains to facilitate KSHV K7 degradation.
polyubiquitin (show UBB Proteins) chains by USP5 at sites of damage is important for efficient DSB repair
Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome (show Psmd4 Proteins) in vascular smooth muscle cells.
Production of the USP5 isoform 2 was strongly correlated with PTBP1 (show PTBP1 Proteins) expression in glioblastoma tumor samples and cell lines.
USP5 uses multiple zinc fluoride (ZnF)-ubiquitin binding protein (UBP (show SGTA Proteins)) domains for substrate targeting and core catalytic function.
Suramin and Cav3.2 (show CACNA1H Proteins)/USP5 Tat (show TAT Proteins)-disruptor peptides were also tested in models of diabetic neuropathy and visceral pain, and provided remarkable protection
Knockdown and overexpression studies demonstrated that Usp5 regulates p53 (show TP53 Proteins) (and p73 (show ARHGAP24 Proteins)) levels and alters cell growth and cell cycle distribution associated with p21 induction.
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995
ubiquitin carboxyl-terminal hydrolase 5
, Ubiquitin isopeptidase T
, ubiquitin specific peptidase 5 (isopeptidase T) isoform 1
, ubiquitin specific peptidase 5 (isopeptidase T) isoform 2
, ubiquitin specific protease 5
, ubiquitin specific peptidase 5
, deubiquitinating enzyme 5
, isopeptidase T
, ubiquitin isopeptidase T
, ubiquitin specific protease 5 (isopeptidase T)
, ubiquitin thioesterase 5
, ubiquitin thiolesterase 5
, ubiquitin-specific protease-5 (ubiquitin isopeptidase T)
, ubiquitin-specific-processing protease 5
, ubiquitin carboxy terminal hydrolase T