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Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Additionally we are shipping USP7 Proteins (8) and many more products for this protein.
Showing 10 out of 153 products:
Human Polyclonal USP7 Primary Antibody for ICC, IF - ABIN151954
Canning, Boutell, Parkinson, Everett: A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. in The Journal of biological chemistry 2004
Show all 25 references for ABIN151954
Human Polyclonal USP7 Primary Antibody for EIA, IHC (p) - ABIN357533
Puente, Sánchez, Overall, López-Otín: Human and mouse proteases: a comparative genomic approach. in Nature reviews. Genetics 2003
Show all 5 references for ABIN357533
Cow (Bovine) Polyclonal USP7 Primary Antibody for EIA, WB - ABIN401255
Sheng, Saridakis, Sarkari, Duan, Wu, Arrowsmith, Frappier: Molecular recognition of p53 and MDM2 by USP7/HAUSP. in Nature structural & molecular biology 2006
Show all 5 references for ABIN401255
Human Polyclonal USP7 Primary Antibody for EIA, WB - ABIN955493
Sarkari, La Delfa, Arrowsmith, Frappier, Sheng, Saridakis: Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7. in Journal of molecular biology 2010
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Human Monoclonal USP7 Primary Antibody for EIA, WB - ABIN1109455
Becker, Marchenko, Maurice, Moll: Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. in Cell death and differentiation 2007
Show all 3 references for ABIN1109455
Human Monoclonal USP7 Primary Antibody for ELISA, WB - ABIN969186
Daubeuf, Singh, Tan, Liu, Federoff, Bowers, Tolba: HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. in Blood 2009
Show all 3 references for ABIN969186
reveal a conserved mechanism by which Ci/Gli (show GLI1 Antibodies) is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers
Genetic and gene expression analyses suggested that GMPS (show GMPS Antibodies)/USP7 acts as a transcriptional corepressor
GMP synthetase (show GMPS Antibodies) stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
demonstrate that genotoxic stress stimulates Cry1 (show CRY1 Antibodies) phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 (show CRY1 Antibodies) and shifting circadian clock time
Our results demonstrate that the SCML2 (show SCML2 Antibodies)/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis
USP7-mediated mono-deubiquitination of FoxO1 (show FOXO1 Antibodies) results in suppression of FoxO1 (show FOXO1 Antibodies) transcriptional activity through decreased FoxO1 (show FOXO1 Antibodies) occupancy on the promoters of gluconeogenic genes.
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60 (show KAT5 Antibodies).
The ubiquitination-deubiquitination cascade mediated by the TRIM27 (show RFP Antibodies)-USP7 complex plays an important role in TNF-alpha (show TNF Antibodies)-induced apoptosis.
the stability and activity of PPARgamma2 (show PPARG Antibodies) are modulated by the deubiquitinating activity of HAUSP, which may be a target for the development of anti-diabetic drugs.
data reveal a molecular mechanism in which rapid temporal control of Foxp3 (show FOXP3 Antibodies) expression in Treg cells can be regulated by USP7, thereby modulating Treg cell numbers and function
These results indicate that HAUSP-mediated p53 (show TP53 Antibodies) regulation is crucial for brain development, and also suggest that both the p53 (show TP53 Antibodies)-dependent and the p53 (show TP53 Antibodies)-independent functions of HAUSP contribute to the neonatal lethality of hausp-mutant mice.
HAUSP knockout mice embryos showed p53 (show TP53 Antibodies) activation, but no increase in apoptosis.
USP7 (HAUSP) is proteolytically processed upon dexamethasone-, gamma-irradiation-, and antigen-induced cell death. Such processing of HAUSP does not occur in caspase 3 (show CASP3 Antibodies)-/- thymocytes.
USP7 forms a trimeric complex with MDM2 (show MDM2 Antibodies) protein and suppressor of variegation 3-9 homolog 1 (show SUV39H1 Antibodies) protein, independent of DNA, and modulates MDM2 (show MDM2 Antibodies) protein-dependent suppressor of variegation 3-9 homolog 1 (show SUV39H1 Antibodies) protein ubiquitination.
stabilization of UVSSA (show KIAA1530 Antibodies) by interaction with USP7 is essential for Transcription-coupled Nucleotide Excision Repair
USP7 suppresses H2O2-induced mutagenesis involving cell-cycle-independent processes such as DNA repair.
This study identified USP7 as a replisome-enriched SUMO deubiquitinase that is essential for DNA replication.
We now report the identification of a novel molecular function of STIP (show ELP2 Antibodies) that links USP7 to the p53 (show TP53 Antibodies)-Mdm2 (show MDM2 Antibodies) pathway
USP7 interacts with vIRF1 in U2OS cells.
HAUSP-nucleolin (show NCL Antibodies) interaction is regulated by p53 (show TP53 Antibodies)-Mdm2 (show MDM2 Antibodies) complex in response to DNA damage.
USP7-mediated de-ubiquitylation protects Rad18 (show RAD18 Antibodies) from proteasomal degradation and is necessary for the integrity of the specialized translesion synthesis pathway
USP7 allosterically regulates the conformational states of UHRF1 (show UHRF1 Antibodies) and affects chromatin association of UHRF1 (show UHRF1 Antibodies).
Taken together, our results reveal that oxidative and ER stress, rather than the Mdm2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies) axis, mainly contributes to USP7 inhibitor-mediated apoptosis in cancer cells.
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).
, ubiquitin specific peptidase 7 (herpes virus-associated)
, ubiquitin carboxyl-terminal hydrolase 7-like
, deubiquitinating enzyme 7
, herpesvirus-associated ubiquitin-specific protease
, ubiquitin carboxyl-terminal hydrolase 7
, ubiquitin specific protease 7
, ubiquitin thioesterase 7
, ubiquitin thiolesterase 7
, ubiquitin-specific-processing protease 7
, Herpes virus-associated ubiquitin-specific protease
, ubiquitin specific protease 7 (herpes virus-associated)
, herpes-virus-associated ubiquitin-specific protease
, ubiquitin-specific peptidase 7