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Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) Proteins (USP7)

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Additionally we are shipping USP7 Antibodies (133) and USP7 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse USP7 USP7 252870 Q6A4J8
USP7 7874 Q93009
Rat USP7 USP7 360471 Q4VSI4
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Top USP7 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
$140.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 to 8 Days
$258.30
Details
HOST_Sf-21 Cells Human His tag   25 μg Log in to see 5 to 8 Days
$523.95
Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag   100 μg Log in to see 16 Days
$437.80
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

USP7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,

More Proteins for Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) Interaction Partners

Fruit Fly (Drosophila melanogaster) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. reveal a conserved mechanism by which Ci/Gli (show GLI1 Proteins) is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers

  2. Genetic and gene expression analyses suggested that GMPS (show GMPS Proteins)/USP7 acts as a transcriptional corepressor

  3. GMP synthetase (show GMPS Proteins) stimulates histone H2B deubiquitylation by the epigenetic silencer USP7

Mouse (Murine) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. demonstrate that genotoxic stress stimulates Cry1 (show CRY1 Proteins) phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 (show CRY1 Proteins) and shifting circadian clock time

  2. Our results demonstrate that the SCML2 (show SCML2 Proteins)/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis

  3. USP7-mediated mono-deubiquitination of FoxO1 (show FOXO1 Proteins) results in suppression of FoxO1 (show FOXO1 Proteins) transcriptional activity through decreased FoxO1 (show FOXO1 Proteins) occupancy on the promoters of gluconeogenic genes.

  4. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60 (show KAT5 Proteins).

  5. The ubiquitination-deubiquitination cascade mediated by the TRIM27 (show RFP Proteins)-USP7 complex plays an important role in TNF-alpha (show TNF Proteins)-induced apoptosis.

  6. the stability and activity of PPARgamma2 (show PPARG Proteins) are modulated by the deubiquitinating activity of HAUSP, which may be a target for the development of anti-diabetic drugs.

  7. data reveal a molecular mechanism in which rapid temporal control of Foxp3 (show FOXP3 Proteins) expression in Treg cells can be regulated by USP7, thereby modulating Treg cell numbers and function

  8. These results indicate that HAUSP-mediated p53 (show TP53 Proteins) regulation is crucial for brain development, and also suggest that both the p53 (show TP53 Proteins)-dependent and the p53 (show TP53 Proteins)-independent functions of HAUSP contribute to the neonatal lethality of hausp-mutant mice.

  9. HAUSP knockout mice embryos showed p53 (show TP53 Proteins) activation, but no increase in apoptosis.

  10. USP7 (HAUSP) is proteolytically processed upon dexamethasone-, gamma-irradiation-, and antigen-induced cell death. Such processing of HAUSP does not occur in caspase 3 (show CASP3 Proteins)-/- thymocytes.

Human Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. USP7 suppresses H2O2-induced mutagenesis involving cell-cycle-independent processes such as DNA repair.

  2. This study identified USP7 as a replisome-enriched SUMO deubiquitinase that is essential for DNA replication.

  3. We now report the identification of a novel molecular function of STIP (show ELP2 Proteins) that links USP7 to the p53 (show TP53 Proteins)-Mdm2 (show MDM2 Proteins) pathway

  4. USP7 interacts with vIRF1 in U2OS cells.

  5. HAUSP-nucleolin (show NCL Proteins) interaction is regulated by p53 (show TP53 Proteins)-Mdm2 (show MDM2 Proteins) complex in response to DNA damage.

  6. USP7-mediated de-ubiquitylation protects Rad18 (show RAD18 Proteins) from proteasomal degradation and is necessary for the integrity of the specialized translesion synthesis pathway

  7. USP7 allosterically regulates the conformational states of UHRF1 (show UHRF1 Proteins) and affects chromatin association of UHRF1 (show UHRF1 Proteins).

  8. Taken together, our results reveal that oxidative and ER stress, rather than the Mdm2 (show MDM2 Proteins)-p53 (show TP53 Proteins) axis, mainly contributes to USP7 inhibitor-mediated apoptosis in cancer cells.

  9. Data suggest that ubiquitin thioesterase 7 (HAUSP) may act as an oncogenic protein that can modulate c-MYC protein expression via transformation-transcription domain-associated protein (TRRAP).

  10. These studies reveal that USP7-mediated stabilization of DNMT1 (show DNMT1 Proteins) is regulated by acetylation and provide a structural basis for the design of inhibitors.

USP7 Protein Profile

Protein Summary

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).

Gene names and symbols associated with USP7

  • ubiquitin-specific protease 7 (Usp7)
  • ubiquitin specific peptidase 7 (herpes virus-associated) (usp7)
  • ubiquitin specific peptidase 7 (herpes virus-associated) (USP7)
  • ubiquitin specific peptidase 7 (Usp7)
  • ubiquitin specific peptidase 7 (herpes virus-associated) (Usp7)
  • 2210010O09Rik protein
  • AA409944 protein
  • AA617399 protein
  • AU019296 protein
  • AW548146 protein
  • C80752 protein
  • CG1490 protein
  • Dmel\\CG1490 protein
  • HAUSP protein
  • TEF1 protein
  • UBP protein
  • USP7 protein

Protein level used designations for USP7

CG1490-PB , Usp7-PB , ubiquitin specific peptidase 7 (herpes virus-associated) , ubiquitin carboxyl-terminal hydrolase 7-like , deubiquitinating enzyme 7 , herpesvirus-associated ubiquitin-specific protease , mHAUSP , ubiquitin carboxyl-terminal hydrolase 7 , ubiquitin specific protease 7 , ubiquitin thioesterase 7 , ubiquitin thiolesterase 7 , ubiquitin-specific-processing protease 7 , Herpes virus-associated ubiquitin-specific protease , ubiquitin specific protease 7 (herpes virus-associated) , herpes-virus-associated ubiquitin-specific protease , rHAUSP , ubiquitin-specific peptidase 7

GENE ID SPECIES
32169 Drosophila melanogaster
100201254 Hydra magnipapillata
100468835 Ailuropoda melanoleuca
252870 Mus musculus
7874 Homo sapiens
360471 Rattus norvegicus
395126 Gallus gallus
479854 Canis lupus familiaris
100190899 Sus scrofa
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