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anti-Ubiquitin Specific Peptidase 8 (USP8) Antibodies

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Additionally we are shipping USP8 Kits (9) and USP8 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
USP8 9101 P40818
Anti-Rat USP8 USP8 296121  
USP8 84092 Q80U87
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Top anti-USP8 Antibodies at antibodies-online.com

Showing 10 out of 86 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB The anti-USP8 Pab (ABIN388890) is used in Western blot to detect USP8 in transfected 293T cells. Data is kindly provided by Lily Yen from University of California Davis (Davis, CA). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-USP8 Pab (ABIN388891) is used in Western blot to detect USP8 in transfected 293T cells. Data is kindly provided by Lily Yen from University of California Davis (Davis, CA). USP8-C1072 (ABIN388891) western blot analysis in WiDr cell line lysates (35 µg/lane).This demonstrates the USP8 antibody detected the USP8 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-USP8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate WB Suggested Anti-USP8  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control:.93T cell lysate  USP8 is supported by BioGPS gene expression data to be expressed in HEK293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-USP8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HCT15 cell lysate WB Suggested Anti-USP8  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: HCT15 cell lysate  USP8 is supported by BioGPS gene expression data to be expressed in HCT15 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$304.50
Details
Human Mouse Un-conjugated WB USP8 Antibody (C1072)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the USP8 antibody detected the USP8 protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

USP8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
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Mouse (Murine)


Top referenced anti-USP8 Antibodies

  1. Human Polyclonal USP8 Primary Antibody for EIA, IHC (p) - ABIN357537 : Soncini, Berdo, Draetta: Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. in Oncogene 2001 (PubMed)
    Show all 3 references for ABIN357537

  2. Human Polyclonal USP8 Primary Antibody for EIA, IHC (p) - ABIN357535 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 references for ABIN357535

  3. Human Polyclonal USP8 Primary Antibody for EIA, WB - ABIN357534 : Naviglio, Mattecucci, Matoskova, Nagase, Nomura, Di Fiore, Draetta: UBPY: a growth-regulated human ubiquitin isopeptidase. in The EMBO journal 1998 (PubMed)
    Show all 3 references for ABIN357534

More Antibodies against USP8 Interaction Partners

Human Ubiquitin Specific Peptidase 8 (USP8) interaction partners

  1. USP8 regulates VEGFR2 (show KDR Antibodies) trafficking, signaling and proteolysis.

  2. Ubpy loss of function results in the accumulation of autophagosomes due to a blockade of the autophagy flux.

  3. Results show that in addition to the scaffolding function in complex formation, BRUCE (show BIRC6 Antibodies) has an E3 ligase function to promote BRIT1 (show MCPH1 Antibodies) deubiquitination by USP8 leading to accumulation of BRIT1 (show MCPH1 Antibodies) at DNA double-strand break.

  4. No somatic mutations were observed in USP8 in a cohort of GH-secreting pituitary adenomas.

  5. Studies indicate that ubiquitin specific protease 8 protein (USP8) mutations contribute to adrenocorticotropic hormone (ACTH) overproduction in Cushing's disease (CD).

  6. The presence of USP8 mutations may predict favorable responses to the somatostatin (show SST Antibodies) analog pasireotide in corticotroph adenomas of Cushing's disease.

  7. The identification of USP8 mutations as contributors to the pathogenesis of ACTH (show POMC Antibodies)-secreting pituitary adenomas represents an exciting advance in our understanding of Cushing's disease and its potential treatment into the of precision medicine.

  8. these findings implicate a novel role for K6-linked Ub conjugates and USP8-mediated deubiquitination in the regulation of PARK2 (show PARK2 Antibodies) in mitochondrial quality control

  9. In surgically resected primary USP8-mutated tumor cells, USP8 knockdown or blocking EGFR (show EGFR Antibodies) effectively attenuates ACTH (show POMC Antibodies) secretion. Inhibition of USP8 or EGFR (show EGFR Antibodies) is promising for treating USP8-mutated corticotrophin adenoma.

  10. USP8 is frequently mutated in adenomas causing Cushing's disease, especially in those from female adult patients diagnosed at a younger age.

Mouse (Murine) Ubiquitin Specific Peptidase 8 (USP8) interaction partners

  1. the membrane receptor MET, described herein for the first time in spermatids, is a USP8/UBPy-target substrate is delivered to the acrosome.

  2. in neuronal cells USP8 could be involved in endosomal trafficking, retrograde transport and synaptic plasticity. In disorders leading to neurodegeneration USP8 is upregulated and could influence the neuron-oligodendrocyte interactions.

  3. The spatio-temporal expression of mUBPy suggests that the enzyme may be involved in neuroregulatory processes during embryogenesis.

  4. a role for the USP8.STAM (show STAM Antibodies) complex as a protective mechanism regulating early endosomal sorting of EGFR (show EGFR Antibodies) between pathways destined for lysosomal degradation and recycling.

  5. USP8 was able to interact with spermatid endosomal-sorting complex required for transport-0 and microtubule structures; USP8 can directly link, via its MIT domain, the labeled vesicles/developing acrosome to microtubules.

  6. in wobbler testis expression of mouse ubiquitin-specific processing protease (mUBPy)is up-regulated, while a differential sorting of the protein characterizes wobbler spermatids where acrosome formation is impaired

  7. Data indicate a novel mechanism where diacylglycerol kinase delta (show DGKD Antibodies) and protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies) modulate the levels of ubiquitinated epidermal growth factor (show EGF Antibodies) receptors through Akt (show AKT1 Antibodies) and ubiquitin-specific protease 8.

  8. deubiquitinating enzyme specifically expressed in testis (show XKR3 Antibodies), associates with the acrosome and centrosome in mouse germ cells

  9. Results indicate that Nrdp1 (show RNF41 Antibodies) is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 (show RNF41 Antibodies) activity by mediating its stabilization.

  10. We conclude that UBPY negatively regulates the rate of EGFR (show EGFR Antibodies) down-regulation by deubiquitinating EGFR (show EGFR Antibodies) on endosomes.

USP8 Antigen Profile

Protein Summary

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

Gene names and symbols associated with USP8

  • ubiquitin carboxyl-terminal hydrolase 8 (ARALYDRAFT_326514) antibody
  • ubiquitin carboxyl-terminal hydrolase 8 (MGYG_00369) antibody
  • ubiquitin specific peptidase 8 (USP8) antibody
  • ubiquitin specific peptidase 8 (Usp8) antibody
  • ubiquitin specific peptidase 8 (LOC100351436) antibody
  • AI574262 antibody
  • AW557536 antibody
  • HumORF8 antibody
  • mKIAA0055 antibody
  • Ubpy antibody

Protein level used designations for USP8

ubiquitin carboxyl-terminal hydrolase 8 , ubiquitin-specific-processing protease 8 , ubiquitin specific peptidase 8 , ubiquitin carboxyl-terminal hydrolase 8-like , deubiquitinating enzyme 8 , hUBPy , ubiquitin isopeptidase Y , ubiquitin specific protease 8 , ubiquitin thioesterase 8 , ubiquitin thiolesterase 8 , putative deubiquitinating enzyme

GENE ID SPECIES
9310109 Arabidopsis lyrata subsp. lyrata
10031598 Arthroderma gypseum CBS 118893
100408559 Callithrix jacchus
100437819 Pongo abelii
9101 Homo sapiens
296121 Rattus norvegicus
84092 Mus musculus
100157546 Sus scrofa
415451 Gallus gallus
100351436 Oryctolagus cuniculus
100720255 Cavia porcellus
Selected quality suppliers for anti-USP8 (USP8) Antibodies
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