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USP9X is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Additionally we are shipping USP9X Proteins (2) and many more products for this protein.
Showing 10 out of 83 products:
Human Monoclonal USP9X Primary Antibody for IF, ELISA - ABIN563570
Mazumder, Choudhary, Al-Harbi, Almasan: Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells. in Cancer research 2012
Show all 5 references for ABIN563570
In B lymphocytes, Usp9X is required for the induction of PKCbeta kinase activity after B-Cell Antigen Receptor-dependent activation.
Usp9X is a positive regulator of proximal TCR signaling in peripheral T cells and also contributes to T cell tolerance established during intrathymic development.
we identified USP9X as a potential therapeutic target in prostate cancer cells and established WP1130 as a lead compound for the development of ERG (show ERG Antibodies)-depleting drugs.
Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta (show TGFB1 Antibodies)-mediated axonogenesis.
USP9X is a crucial positive regulator of the T Cell Receptor signaling pathway and is required for T-cell function through the modulation of Carma1 (show CARD11 Antibodies)-Bcl10 (show BCL10 Antibodies)-Malt1 (show MALT1 Antibodies) complex formation.
the deubiquitinase USP9X as a novel mTORC1 and -2 binding partner that negatively regulates mTOR (show FRAP1 Antibodies) activity and skeletal muscle differentiation.
loss of Usp9x enhances transformation and protects pancreatic cancer cells from anoikis
Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.
Expressed in both germ cell and supporting cell (show PTPRJ Antibodies) lineages during mouse gonadal development in stage- and sex-dependent manners.
Usp9x is significantly higher in the adult female mouse brains than in male brains. This implies that the difference in sex chromosome complement between XY males and XX females could potentially contribute to sexual differentiation of brain structure.
study reports for the first time that USP9X is a deubiquitinase of Angiomotin-like 2 (AMOTL2 (show AMOTL2 Antibodies)) and that AMOTL2 (show AMOTL2 Antibodies) mono-ubiquitination is required for YAP (show YAP1 Antibodies) inhibition
USP9x interacted with and stabilized beta-catenin (show CTNNB1 Antibodies) through deubiquitination to mediate transcription of the decoy receptors in breast cancer cells
We examined the role of USP9X in the primary cilium of affected females with ciliopathy syndromes and found that endogenous USP9X localizes along the length of the ciliary axoneme, so its loss of function could disrupt cilium-regulated processes.
These data support the use of MCL1 (show MCL1 Antibodies) expression as a predictive biomarker for USP9X inhibitors in non-small cell lung cancer therapy
The mammalian PRICKLE-interactome was defined, identifying prickle-interacting proteins that localize to synapses and a novel interacting partner, USP9X, a substrate-specific de-ubiquitinase. PRICKLE and USP9X interact through their carboxy-termini; and USP9X de-ubiquitinates PRICKLE, protecting it from proteasomal degradation.
the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 (show USP24 Antibodies) activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice.
Noxa (show PMAIP1 Antibodies) upregulation reduces the availability of Usp9x to Mcl-1 (show MCL1 Antibodies), thereby promoting its ubiquitination and degradation, leading to the apoptosis of neoplastic cells.
Although USP9X may function as a tumor-suppressor during the establishment of PDAC, data presented here argue that USP9X promotes cell growth in advanced PDAC cells when PDAC is typically diagnosed.
Our analysis of clinical HCC (show FAM126A Antibodies) samples verifies that miR (show MLXIP Antibodies)-26b also targets USP9X expression to inhibit the EMT (show ITK Antibodies) of hepatocytes
USP9X downregulation renders breast cancer cells resistant to tamoxifen.
This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
probable ubiquitin carboxyl-terminal hydrolase FAF-X
, ubiquitin specific peptidase 9, X chromosome
, ubiquitin specific peptidase 9, X-linked
, ubiquitin specific protease 9, X-linked
, probable ubiquitin carboxyl-terminal hydrolase FAF-X-like
, deubiquitinating enzyme FAF-X
, fat facets homolog
, fat facets protein-related, X-linked
, fats facets protein related, X
, ubiquitin carboxyl-terminal hydrolase FAM
, ubiquitin specific protease 9 SSSRF- isoform
, ubiquitin specific protease 9, X chromosome
, ubiquitin thioesterase FAF-X
, ubiquitin thiolesterase FAF-X
, ubiquitin-specific protease 9, X chromosome
, ubiquitin-specific-processing protease FAF-X
, Drosophila fat facets related, X-linked
, fat facets in mammals
, fat facets protein related, X-linked
, ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila)
, ubiquitin-specific processing protease FAF-X