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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2A Proteins (16) and Ubiquitin-Conjugating Enzyme E2A Kits (11) and many more products for this protein.
Showing 10 out of 47 products:
Human Monoclonal ube2a Primary Antibody for ELISA, WB - ABIN393708
Nascimento, Otto, de Brouwer, Vianna-Morgante: UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome. in American journal of human genetics 2006
Show all 5 references for ABIN393708
Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.
Results showed KCMF1 (show KCMF1 Antibodies) C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 (show UBR4 Antibodies) and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 (show KCMF1 Antibodies) and UBR4 (show UBR4 Antibodies).
This study investigates clinical and molecular data of two unrelated, affected males with chromosome Xq24 deletions encompassing UBE2A.
RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha (show CBX5 Antibodies) at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway
HHR6 and hRad18 (show RAD18 Antibodies) can monoubiquitinate FANCD2 (show FANCD2 Antibodies) at lysine 561 in vitro. This activity may represent a novel stress response pathway.
RNF168 (show RNF168 Antibodies), in complex with RAD6A or RAD6B (show UBE2B Antibodies), is activated in the DNA-damage-induced protein ubiquitination cascade.
RAD6A is a regulator of Parkin (show PARK2 Antibodies)-dependent mitophagy plays a critical role in maintaining neuronal function.
UBE2A specifically interacts with CDK9 (show CDK9 Antibodies), but not CDK2 (show CDK2 Antibodies) and is phosphorylated by CDK9 (show CDK9 Antibodies) in vitro.
RAD6 can form a ternary complex with MDM2 (show MDM2 Antibodies) and p53 (show TP53 Antibodies) that contributes to the degradation of p53 (show TP53 Antibodies).
UBE2A deficiency syndrome is reported in two male patients.
results indicate a causal role of UBE2A in learning and mGLUR (show GRM8 Antibodies)-dependent long-term depression
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A (show TCF3 Antibodies)-deficient mice.
signaling through Notch (show NOTCH1 Antibodies) modulates the turnover of E2A (show TCF3 Antibodies) proteins
absence of mHR6A in oocytes prevents development beyond the embryonic two-cell stage
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
ubiquitin-conjugating enzyme E2 A
, ubiquitin-conjugating enzyme E2A (RAD6 homolog)
, ubiquitin-conjugating enzyme E2A
, RAD6 homolog A
, ubiquitin carrier protein A
, ubiquitin-protein ligase A
, ubiquitin-conjugating enzyme E2A, RAD6 homolog
, ubiquitin-conjugating enzyme HR6A