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Ubiquitin-Conjugating Enzyme E2A Proteins (ube2a)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2A Antibodies (45) and Ubiquitin-Conjugating Enzyme E2A Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ube2a 7319 P49459
Mouse ube2a ube2a 22209 Q9Z255
Rat ube2a ube2a 298317  
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Top Ubiquitin-Conjugating Enzyme E2A Proteins at antibodies-online.com

Showing 8 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$173.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$322.14
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 10 to 12 Days
$237.60
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

ube2a Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

Top referenced Ubiquitin-Conjugating Enzyme E2A Proteins

  1. Human ube2a Protein expressed in Escherichia coli (E. coli) - ABIN666994 : Sarcevic, Mawson, Baker, Sutherland: Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation. in The EMBO journal 2002 (PubMed)
    Show all 2 references for ABIN666994

  2. Human ube2a Protein expressed in Escherichia coli (E. coli) - ABIN2005315 : Nascimento, Otto, de Brouwer, Vianna-Morgante: UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome. in American journal of human genetics 2006 (PubMed)

More Proteins for Ubiquitin-Conjugating Enzyme E2A (ube2a) Interaction Partners

Human Ubiquitin-Conjugating Enzyme E2A (ube2a) interaction partners

  1. Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.

  2. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4.

  3. This study investigates clinical and molecular data of two unrelated, affected males with chromosome Xq24 deletions encompassing UBE2A.

  4. RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha (show CBX5 Proteins) at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway

  5. HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway.

  6. RNF168 (show RNF168 Proteins), in complex with RAD6A or RAD6B (show UBE2B Proteins), is activated in the DNA-damage-induced protein ubiquitination cascade.

  7. RAD6A is a regulator of Parkin (show PARK2 Proteins)-dependent mitophagy plays a critical role in maintaining neuronal function.

  8. UBE2A specifically interacts with CDK9 (show CDK9 Proteins), but not CDK2 (show CDK2 Proteins) and is phosphorylated by CDK9 (show CDK9 Proteins) in vitro.

  9. RAD6 can form a ternary complex with MDM2 (show MDM2 Proteins) and p53 (show TP53 Proteins) that contributes to the degradation of p53 (show TP53 Proteins).

  10. UBE2A deficiency syndrome is reported in two male patients.

Mouse (Murine) Ubiquitin-Conjugating Enzyme E2A (ube2a) interaction partners

  1. results indicate a causal role of UBE2A in learning and mGLUR (show GRM8 Proteins)-dependent long-term depression

  2. RNF168 (show RNF168 Proteins), in complex with RAD6A or RAD6B (show UBE2B Proteins), is activated in the DNA-damage-induced protein ubiquitination cascade.

  3. Disruption of pre-TCR expression accelerates lymphomagenesis in E2A (show TCF3 Proteins)-deficient mice.

  4. signaling through Notch (show NOTCH1 Proteins) modulates the turnover of E2A (show TCF3 Proteins) proteins

  5. absence of mHR6A in oocytes prevents development beyond the embryonic two-cell stage

Ubiquitin-Conjugating Enzyme E2A (ube2a) Protein Profile

Protein Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Gene names and symbols associated with ube2a

  • ubiquitin-conjugating enzyme E2A (UBE2A)
  • ubiquitin-conjugating enzyme E2A (ube2a)
  • ubiquitin-conjugating enzyme E2A (RAD6 homolog) (ube2a)
  • ubiquitin-conjugating enzyme E2A (Ube2a)
  • ubiquitin-conjugating enzyme E2A (LOC100154142)
  • BHR6A protein
  • HHR6A protein
  • HR6A protein
  • Mhr6a protein
  • mp:zf637-2-000771 protein
  • MRXS30 protein
  • MRXSN protein
  • RAD6A protein
  • si:bz46j2.4 protein
  • UBC2 protein
  • wu:fa01h11 protein

Protein level used designations for ube2a

ubiquitin-conjugating enzyme E2 A , ubiquitin-conjugating enzyme E2A (RAD6 homolog) , ubiquitin-conjugating enzyme E2A , RAD6 homolog A , ubiquitin carrier protein A , ubiquitin-protein ligase A , ubiquitin-conjugating enzyme E2A, RAD6 homolog , ubiquitin-conjugating enzyme HR6A

GENE ID SPECIES
282107 Bos taurus
398788 Xenopus laevis
448176 Xenopus (Silurana) tropicalis
492095 Canis lupus familiaris
693716 Macaca mulatta
737175 Pan troglodytes
797853 Danio rerio
100058679 Equus caballus
100195873 Salmo salar
100217902 Taeniopygia guttata
7319 Homo sapiens
22209 Mus musculus
298317 Rattus norvegicus
100154142 Sus scrofa
395672 Gallus gallus
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