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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE2C Proteins (28) and UBE2C Kits (9) and many more products for this protein.
Showing 10 out of 139 products:
Human Monoclonal UBE2C Primary Antibody for IF, IHC (p) - ABIN564800
Jiang, Huang, Lu, Luo, Hu, Liu, Chen, Han: Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors. in Brain research 2008
Show all 7 references for ABIN564800
Human Polyclonal UBE2C Primary Antibody for WB - ABIN388855
Okamoto, Ozaki, Miyazaki, Aoyama, Miyazaki, Nakagawara: UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme. in Cancer research 2003
Show all 3 references for ABIN388855
Human Polyclonal UBE2C Primary Antibody for EIA, WB - ABIN453449
Lin, Hwang, Basavappa: Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. in The Journal of biological chemistry 2002
Show all 3 references for ABIN453449
Human Polyclonal UBE2C Primary Antibody for WB - ABIN388856
Townsley, Aristarkhov, Beck, Hershko, Ruderman: Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. in Proceedings of the National Academy of Sciences of the United States of America 1997
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Cow (Bovine) Polyclonal UBE2C Primary Antibody for WB - ABIN2774934
Ieta, Ojima, Tanaka, Nakamura, Haraguchi, Mimori, Inoue, Kuwano, Mori: Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. in International journal of cancer. Journal international du cancer 2007
Identification of UBE2C as a target of wild-type and GOF mutant p53 (show TP53 Antibodies) further highlights the contribution of p53 (show TP53 Antibodies) in regulation of spindle assembly checkpoint
The anaphase-promoting complex/cyclosome C activity in human cells is tuned by the combinatorial use of three E2 ubiquitin-conjugating enzymes, namely UBE2C, UBE2S (show UBE2S Antibodies), and UBE2D.
Study shows an overexpression of UbcH10 mRNA and protein in the vast majority of colorectal cancer (CRC (show CALR Antibodies)) patients analyzed and indicates that UbcH10 expression regulates CRC (show CALR Antibodies) growth.
the present study showed that miR (show MLXIP Antibodies)-196a promoted cell proliferation by targeting UBE2C in breast cancer. Thus, miR (show MLXIP Antibodies)-196a may be a potential oncogene (show RAB1A Antibodies) in breast cancer and a promising therapeutic target in breast cancer treatment.
UBE2C could regulate phospho-ERK1/2 (show MAPK1/3 Antibodies) level.
Data suggest that ubiquitin-conjugating enzyme (show Ube2t Antibodies) UbcH10 may be a promising target for the therapy of breast cancer.
Upregulation of miR-17/20a promotes gastric cancer cell growth by targeting UBE2C.
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
in addition to binding APC11 (show ANAPC11 Antibodies)'s RING, UBCH10 is corecruited via interactions with APC2
excess E2F1 (show E2F1 Antibodies) due to Rb inactivation recruits the complex of Cdc20 (show CDC20 Antibodies) and the anaphase-promoting complex/cyclosome to deregulate the expression of UBCH10
alongside their canonical function in protein degradation, Ube2C and -S also control the extrusion of the first polar body.
results identify UbcH10 as a prominent protooncogene that causes whole chromosome instability and tumor formation over a wide gradient of overexpression levels
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.
ubiquitin-conjugating enzyme E2C
, ubiquitin carrier protein C
, ubiquitin-protein ligase C
, cyclin-selective ubiquitin carrier protein
, mitotic-specific ubiquitin-conjugating enzyme
, ubiquitin-conjugating enzyme E2 C