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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2D 2 Proteins (19) and many more products for this protein.
Showing 10 out of 82 products:
Human Monoclonal UBE2D2 Primary Antibody for WB - ABIN393745
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 5 references for ABIN393745
Human Polyclonal UBE2D2 Primary Antibody for EIA, WB - ABIN955424
Wu, Kovacev, Pan: Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. in Molecular cell 2010
Show all 3 references for ABIN955424
Human Polyclonal UBE2D2 Primary Antibody for WB - ABIN658701
Vina-Vilaseca, Sorkin: Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. in The Journal of biological chemistry 2010
Show all 3 references for ABIN658701
Cow (Bovine) Polyclonal UBE2D2 Primary Antibody for IHC, WB - ABIN2775673
Desforges, Lacey, Glazier, Greenwood, Mynett, Speake, Sibley: SNAT4 isoform of system A amino acid transporter is expressed in human placenta. in American journal of physiology. Cell physiology 2005
Caenorhabditis elegans (C. elegans) Polyclonal UBE2D2 Primary Antibody for WB - ABIN2775675
Guinn, Bland, Lodi, Liggins, Tobal, Petters, Wells, Banham, Mufti: Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. in Biochemical and biophysical research communications 2005
Human Monoclonal UBE2D2 Primary Antibody for IHC (p), ELISA - ABIN521212
Peters, Rees, Hardwick, Hardwick, Vowler, Ong, Zhang, Save, ODonovan, Rassl, Alderson, Caldas, Fitzgerald: A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia. in Gastroenterology 2010
mutations having marked effects on function only minimally affect the intermolecular interactions between the AO7 (show RNF25 Antibodies) RING and UbcH5B, establishing a high degree of complexity in activation through the RING-E2 interface.
Data show that ubiquitin E2 enzymes UBE2D1 (show UBE2D1 Antibodies)/2/3 and E3 ligase RNF138 (show RNF138 Antibodies) accumulate at DNA-damage sites and act at early resection stages by promoting CtIP (show RBBP8 Antibodies) protein ubiquitylation and accrual.
together with UBE2L3 (show UBE2L3 Antibodies) and UBE2N (show UBE2N Antibodies), synergistically contribute to Parkin (show PARK2 Antibodies)-mediated mitophagy
Presented is the structure of the human dimeric RING domain from BIRC7 (show BIRC7 Antibodies) in complex with the E2 UbcH5B covalently linked to Ub.
Whereas UbcH5(A, B and C) is highly efficient in converting IkBa into monoubiquitinated forms, Cdc34 drives ubiquitin (Ub)-Ub conjugation
determined the 2.2 A crystal structure of an intermediate of UbcH5b approximately ubiquitin (Ub) conjugate, which is assembled into an infinite spiral through the backside interaction.
role of WW3 and WW4 domains of Nedd4-2 in dopamine transporter ubiquitination was demonstrated; siRNA analysis demonstrated that this polyubiquitination is mediated by Nedd4-2 cooperation with UBE2D and UBE2L3 E2 ubiquitin-conjugating enzymes
Results describe the crystal structure of a complex between the HECT domain of NEDD4L (show NEDD4L Antibodies) and the E2 UbcH5B bearing a covalently linked Ub at its active site (UbcH5B approximately Ub).
Data show that binding of the CNOT4 (show CNOT4 Antibodies) RING finger (show PCGF1 Antibodies) to the ubiquitin-conjugating enzyme (E2 (show UBE2D4 Antibodies)) UbcH5B is highly selective.
UbcH5B/C are E2s for Mdm2 (show MDM2 Antibodies), which contribute to the maintenance of low levels of p53 (show TP53 Antibodies) and Mdm2 (show MDM2 Antibodies) in unstressed cells; inhibition of p53 (show TP53 Antibodies) ubiquitination and degradation by targeting UbcH5B/C is not sufficient to up-regulate p53 (show TP53 Antibodies) transcriptional activity.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
ubiquitin-conjugating enzyme E2D 2
, ubiquitin-conjugating enzyme E2 D2
, p53-regulated ubiquitin-conjugating enzyme 1
, ubiquitin carrier protein D2
, ubiquitin-conjugating enzyme E2-17 kDa 2
, ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)
, ubiquitin-protein ligase D2
, E2(17)KB 2
, ubc2e ubiquitin conjugating enzyme
, ubiquitin-conjugating enzyme E2(17)KB 2
, ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
, ubiquitin-conjugating enzyme E2 D3
, ubiquitin conjugating enzyme 2e
, ubiquitin carrier protein 4
, ubiquitin conjugating enzyme E2
, ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog)