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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE2L3 Antibodies (121) and UBE2L3 Proteins (12) and many more products for this protein.
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Data suggest ordered binding of UBCH7-ubiquitin to E6AP (show ube3a ELISA Kits) Site 1 (for E6AP (show ube3a ELISA Kits)-Cys820/ubiquitin thioester formation) and E6AP (show ube3a ELISA Kits) Site 2 (for subsequent chain elongation); proximal indexation accounts for radially symmetric structure of E6AP (show ube3a ELISA Kits), requirement for oligomerization in polyubiquitin (show UBB ELISA Kits) chain formation, and mechanistic rationale for Cys820-ubiquitin thioester as platform in chain assembly. (E6AP (show ube3a ELISA Kits) = ubiquitin-protein ligase (show UBE2K ELISA Kits) E6AP (show ube3a ELISA Kits))
The TCGGC haplotype is associated with an increased risk of Hashimoto Thyroiditis(HT) and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population.
together with UBE2N (show UBE2N ELISA Kits) and UBE2D2 (show UBE2D2 ELISA Kits), synergistically contribute to Parkin (show PARK2 ELISA Kits)-mediated mitophagy
The MAP1B-LC1 (show MAP1B ELISA Kits) could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and that the ubiquitination/degradation mechanism triggered by MAP1B-LC1 (show MAP1B ELISA Kits) could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway.
An interaction between LC1 (show MAP1B ELISA Kits) and the ubiquitin-conjugating enzyme (show Ube2t ELISA Kits) UBE2L3.
UbcH7 has a role in regulating 53BP1 (show TP53BP1 ELISA Kits) stability and DSB repair
UBE2L3 polymorphism amplifies NF-kappaB (show NFKB1 ELISA Kits) activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.
Report role of UBE2L3 genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
Importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ.
The results suggest that variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBCH7 expression.
UBE2L3 depletion increases pro-IL-1beta (show IL1B ELISA Kits) levels.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene.
ubiquitin-conjugating enzyme E2L 3
, ubiquitin-conjugating enzyme E2 L3
, ubiquitin carrier protein L3
, ubiquitin-protein ligase L3
, ubiquitin-conjugating enzyme E2-F1
, ubiquitin-conjugating enzyme UBCH7
, ubiquitin-conjugating enzyme 7
, ubiquitin-conjugating enzyme E2L 3, like