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Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 Proteins (UHRF1)

May act as a negative regulator of cell growth.. Additionally we are shipping UHRF1 Antibodies (90) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UHRF1 29128 Q96T88
UHRF1 316129 Q7TPK1
Mouse UHRF1 UHRF1 18140 Q8VDF2
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Top UHRF1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,269.83
Details
HOST_Escherichia coli (E. coli) Human GST tag   100 μg Log in to see 14 to 16 Days
$675.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UHRF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

More Proteins for Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) Interaction Partners

Human Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. Results showed that UHRF1 was overexpressed in almost all of the prostate cancer cell (PCa (show FLVCR1 Proteins)) lines. Its expression levels were correlated with some clinical features of PCa (show FLVCR1 Proteins) suggesting it as an independent prognostic factor for biochemical recurrence.

  2. UHRF1 promotes osteosarcoma cell invasion by downregulating the expression of Ecadherin and increasing epithelialtomesenchymal transition in an Rb1dependent manner.

  3. Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone (show HIST1H3B Proteins) recognition.

  4. UHRF1 was over-expressed in hepatocellular carcinoma tissues compared to the adjacent normal tissues and UHRF1 expression shared significant relevance with distant metastasis, cancer area and HBV.

  5. results suggest that UPAT and UHRF1 may be promising molecular targets for the therapy of colon cancer

  6. LASP-1 (show LASP1 Proteins) associated with UHRF1, G9a (show EHMT2 Proteins), Snail1 (show SNAI1 Proteins) and di- and tri (show VANGL2 Proteins)-methylated histoneH3 in a CXCL12 (show CXCL12 Proteins)-dependent manner based on immunoprecipitation and proximity ligation assays

  7. These findings identify ICBP90 as a key regulator of MIF (show AMH Proteins) transcription and provide functional insight into the regulation of the polymorphic MIF (show AMH Proteins) locus.

  8. miR-124 could control the fate of target gene UHRF1 mRNA by binding 3'-UTR

  9. This study showed that UHRF1 interacts directly with BRCA1 and is involved in DNA double-strand break repair.

  10. Findings demonstrated the inhibitory effect of MEG3 (show FAM129B Proteins) in vivo and vitro and illuminated that MEG3 (show FAM129B Proteins) could be a potential biomarker for the survival of hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients. Its expression seemed to be regulated by UHRF1 in HCC (show FAM126A Proteins).

Pig (Porcine) Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Proteins), Dnmt3a (show DNMT3A Proteins), Hdac1 (show HDAC1 Proteins), Kdm3a (show KDM3A Proteins) and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Zebrafish Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. Dnmt1 (show DNMT1 Proteins) stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. DNA hypomethylation is the mechanism underlying the cell cycle block and small liver phenotype caused by uhrf1 depletion.

  3. an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2 (show CDK2 Proteins)/cyclin A2 (show CCNA2 Proteins) during early vertebrate development

  4. These data provide the first evidence that Uhrf1 and Dnmt1 (show DNMT1 Proteins) function is required for vertebrate lens development and maintenance.

  5. uhrf1 is required for physiologic liver growth in both embryos and adults

Mouse (Murine) Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone (show HIST1H3B Proteins) recognition.

  2. the histone modification status at the DMRs of imprinted genes may dictate whether DNA methylation (show HELLS Proteins) could be restored upon UHRF1 re-expression

  3. UHRF1 is strongly up-regulated during liver regeneration independently of BIRC5 (show BIRC5 Proteins).

  4. report identifies PARP1 (show PARP1 Proteins) as a novel modulator of two UHRF1-regulated heterochromatin-associated events: the accumulation of H4K20me3 and the clearance of DNMT1 (show DNMT1 Proteins)

  5. Uhrf1 deficiency resulted in derepression of the gene (Cdkn1a (show CDKN1A Proteins)) that encodes the cyclin-dependent kinase (show CDK1 Proteins) inhibitor p21 due to hypomethylation of its promoter region, which resulted in cell-cycle arrest of Treg cells.

  6. These findings show that apart from the targeting of DNMT1 (show DNMT1 Proteins) to the replicated DNA UHRF1 increases the activity and specificity of DNMT1 (show DNMT1 Proteins), thus exerting a multifaceted influence on the maintenance of DNA methylation (show HELLS Proteins).

  7. The DNA methyltransferase (show DNMT1 Proteins) Dnmt1 (show DNMT1 Proteins) directly interacts with the SET and RING finger (show PCGF1 Proteins)-associated (SRA (show MSR1 Proteins)) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA.

  8. UHRF1 can target DNMT1 (show DNMT1 Proteins) for DNA maintenance methylation through binding either histone 3 lysine 9 methylation 2/3 or hemi-methylated CpG.

  9. The UHRF1 is not functionally redundant in DNA methylation (show HELLS Proteins) maintenance and reveals the cell-cycle-dependent interaction between UHRF1 and DNMT1 (show DNMT1 Proteins) as a key regulatory mechanism targeting DNMT1 (show DNMT1 Proteins) for DNA methylation (show HELLS Proteins).

  10. results reveal that the disruption of Dnmt1 (show DNMT1 Proteins)/PCNA (show PCNA Proteins)/UHRF1 interactions acts as an oncogenic event and that one of its signatures (i.e. the low level of mMTase activity) is a molecular biomarker associated with a poor prognosis in GBM patients

UHRF1 Protein Profile

Protein Summary

May act as a negative regulator of cell growth.

Gene names and symbols associated with UHRF1

  • ubiquitin-like with PHD and ring finger domains 1 (UHRF1)
  • ubiquitin-like with PHD and ring finger domains 1 (Uhrf1)
  • ubiquitin-like, containing PHD and RING finger domains, 1 (uhrf1)
  • ubiquitin-like, containing PHD and RING finger domains, 1 (Uhrf1)
  • UHRF1 binding protein 1 (UHRF1BP1)
  • AL022808 protein
  • C6orf107 protein
  • dJ349A12.1 protein
  • fb97f09 protein
  • hNP95 protein
  • hUHRF1 protein
  • ICBP90 protein
  • NP95 protein
  • RNF106 protein
  • UHRF1 protein
  • wu:fb97f09 protein
  • zgc:63539 protein

Protein level used designations for UHRF1

ubiquitin-like, containing PHD and RING finger domains, 1 , ubiquitin-like with PHD and ring finger domains 1 , E3 ubiquitin-protein ligase UHRF1 , RING finger protein 106 , huNp95 , inverted CCAAT box-binding protein of 90 kDa , nuclear protein 95 , nuclear zinc finger protein Np95 , transcription factor ICBP90 , ubiquitin-like PHD and RING finger domain-containing protein 1 , ubiquitin-like-containing PHD and RING finger domains protein 1 , liver regeneration-related protein LRRG126 , mUhrf1 , ICBP90 binding protein 1 , ICBP90-binding protein 1 , UHRF1 (ICBP90) binding protein 1 , UHRF1-binding protein 1 , ubiquitin-like containing PHD and RING finger domains 1-binding protein 1

GENE ID SPECIES
100062347 Equus caballus
455613 Pan troglodytes
29128 Homo sapiens
530411 Bos taurus
316129 Rattus norvegicus
420154 Gallus gallus
611463 Canis lupus familiaris
100511003 Sus scrofa
100719542 Cavia porcellus
406350 Danio rerio
18140 Mus musculus
54887 Homo sapiens
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