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Ubiquitin-Like Modifier Activating Enzyme 1 Proteins (UBA1)

The protein encoded by UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. Additionally we are shipping UBA1 Antibodies (68) and UBA1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBA1 7317 P22314
Mouse UBA1 UBA1 22201 Q02053
Rat UBA1 UBA1 314432 Q5U300
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Top UBA1 Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$378.00
Details
HOST_Sf-21 Cells Human His tag   50 μg Log in to see 5 to 8 Days
$357.00
Details
HOST_Sf-9 Cells Human GST tag   50 μg Log in to see 5 to 8 Days
$428.40
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$443.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UBA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,

Top referenced UBA1 Proteins

  1. Human UBA1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004962 : Xia, Dimitropoulou, Zeng, Antonova, Snead, Venema, Fulton, Qian, Patterson, Papapetropoulos, Catravas: Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase. in American journal of physiology. Heart and circulatory physiology 2007 (PubMed)

More Proteins for Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) Interaction Partners

Human Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) interaction partners

  1. recent findings put UBA1 at the center of cellular homeostasis and neurodegeneration [review]

  2. A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 (show USP5 Proteins) enzymes.

  3. Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 (show UBD Proteins) targets it for proteasomal degradation

  4. Ubiquitin-activating enzyme is necessary for 17beta-estradiol-induced breast cancer cell proliferation and migration.

  5. Diminished ubiquitylation phenotype observed in enteropathogenic Escherichia coli infected cells corresponds to a strong reduction in the abundance of both Ube1 and Uba6 (show UBA6 Proteins).

  6. Decrease in free ubiquitin levels under stress allows NEDD8 (show NEDD8 Proteins) to be conjugated through Ube1.

  7. UBA1 knockdown impairs formation of ubiquitin conjugates at DNA double-strand breaks.

  8. Data show that largazole and ester/keto analogs inhibit ubiquitin E1 activation.

  9. Ubiquitin and UBE1 are upregulated in tic epilepsy.

  10. In conclusion, nUBE1L is a novel human E1 like gene highly expressed in adult testis, which plays key role in ubiquitin system, and accordingly influences spermatogenesis and male fertility.

Mouse (Murine) Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) interaction partners

  1. Inhibition of ubiquitin-activating enzyme E1 (Ube1) increases the levels of high- molecular weight mouse Htt (show HTT Proteins) in relatively unaffected tissues, declining in the nuclear fraction with age.

  2. Dysregulation of UBA1 and subsequent ubiquitination pathways led to beta-catenin (show CTNNB1 Proteins) accumulation in a model of spinal muscular atrophy.

  3. These data suggest that Cys (show DNAJC5 Proteins)-278 can affect Ub charging through a change in the structural conformation of UBA1, not through direct interaction at the UBA1-Ub interface.

  4. biochemical and crystallographic characterization of the two half-domains and the crystal structure of the larger, second catalytic cysteine half-domain of mouse ubiquitin-activating enzyme

UBA1 Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.

Gene names and symbols associated with UBA1

  • ubiquitin activating enzyme E1 (uae1)
  • ubiquitin-like modifier activating enzyme 1 (uba1-b)
  • ubiquitin-like modifier activating enzyme 1 (uba1-a)
  • ubiquitin-like modifier activating enzyme 1 (uba1)
  • Ubiquitin-conjugating enzyme E1 (GL50803_4083)
  • Ubiquitin-conjugating enzyme E1 (GL50803_10661)
  • ubiquitin-like modifier activating enzyme 1 (UBA1)
  • ubiquitin-like modifier activating enzyme 1 (Uba1)
  • ubiquitin-like modifier activating enzyme 2 (Uba2)
  • A1S9 protein
  • A1S9T protein
  • A1ST protein
  • AA986091 protein
  • AMCX1 protein
  • Arx protein
  • DDBDRAFT_0190927 protein
  • DDBDRAFT_0220497 protein
  • DDB_0190927 protein
  • DDB_0220497 protein
  • GXP1 protein
  • POC20 protein
  • Sae2 protein
  • Sbx protein
  • SMAX2 protein
  • UBA1 protein
  • UBA1A protein
  • uba1b protein
  • ube protein
  • Ube-1 protein
  • UBE1 protein
  • Ube1x protein
  • Ubl1a2 protein
  • Uble1b protein
  • wu:fa01e08 protein
  • wu:fb30f01 protein
  • wu:fi21c11 protein
  • wu:fj14g11 protein
  • zgc:66143 protein

Protein level used designations for UBA1

ubiquitin-activating enzyme E1 , ubiquitin activating enzyme , fb30f01 , ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) , ubiquitin-like modifier-activating enzyme 1 , Ubiquitin-conjugating enzyme E1 , A1S9T and BN75 temperature sensitivity complementing , POC20 centriolar protein homolog , UBA1, ubiquitin-activating enzyme E1 homolog A , ubiquitin-activating enzyme E1, Chr X , SUMO-activating enzyme subunit 2 , SUMO1 activating enzyme subunit 2 , Sumo-1 activating enzyme subunit 2 , anthracycline-associated resistance ARX , ubiquitin-like 1 (sentrin) activating enzyme E1B , ubiquitin-like 1 (sentrin) activating enzyme subunit 2 , ubiquitin-like 1-activating enzyme E1B

GENE ID SPECIES
8617637 Dictyostelium discoideum AX4
379877 Xenopus laevis
398370 Xenopus laevis
406335 Danio rerio
5700601 Giardia lamblia ATCC 50803
5700939 Giardia lamblia ATCC 50803
7317 Homo sapiens
22201 Mus musculus
480896 Canis lupus familiaris
314432 Rattus norvegicus
282869 Bos taurus
100009225 Oryctolagus cuniculus
50995 Mus musculus
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