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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2L 6 Antibodies (71) and Ubiquitin-Conjugating Enzyme E2L 6 Proteins (17) and many more products for this protein.
Depletion of either ISG15 (show ISG15 ELISA Kits) or UBE2L6/UBCH8 resulted in enhanced endogenous autophagic flux.
Data indicate that reduced expression of the ubiquitin-conjugating enzyme (show Ube2t ELISA Kits) UbcH8 protein correlated with poor outcome in nasopharyngeal carcinoma (NPC (show NPC1 ELISA Kits)) patients.
study reports that UBCH8 and UBE2G1 (show Ube2g1 ELISA Kits) and UBE2G2 (show UBE2G2 ELISA Kits) cooperate with CRL4Cdt2 in promoting the polyubiquitylation and subsequent degradation of p21 (show CDKN1A ELISA Kits) and Cdt1 (show CDT1 ELISA Kits), respectively
gain and loss-of-function approaches show that UBCH8 and the ubiquitin-ligase SIAH1 physically interact with and target FLT3 (show FLT3 ELISA Kits)-ITD for proteasomal degradation
The structure of UbcH8 does not undergo a significant conformational change upon forming a complex with ubiquitin.
Quantitative-PCR and Northern analysis confirmed down-regulation of UCRP and UBE2L6 with BRCA2 (show BRCA2 ELISA Kits) knockdown, respectively.
Ube1L was required for transfer of ISG15 to UbcH8 and for binding of Ube1L to UbcH8
we have identified a loss-of-function mutation in Ube2l6 that contributes to the chromosome 2 obesity quantitative trait locus (show MC3R ELISA Kits).
Ubc8 (show UBE2H ELISA Kits) is a major ISG15 (show ISG15 ELISA Kits)-conjugating enzyme responsible for protein ISGylation upon interferon (show IFNA ELISA Kits) stimulation
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
ubiquitin-conjugating enzyme E2L 6
, ubiquitin/ISG15-conjugating enzyme E2 L6
, retinoic acid induced gene B protein
, retinoic acid-induced gene B protein
, ubiquitin carrier protein L6
, ubiquitin-protein ligase L6
, E2 ubiquitin conjugating enzyme
, ubiquitin-conjugating enzyme 8
, Ubiquitin carrier protein L6
, Ubiquitin-protein ligase L6