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May act as a negative regulator of cell growth.. Additionally we are shipping UHRF1 Antibodies (107) and UHRF1 Proteins (7) and many more products for this protein.
A histone H3K9-like mimic within LIG1 (show LIG1 ELISA Kits) is methylated by G9a (show EHMT2 ELISA Kits) and GLP (show RCBTB1 ELISA Kits) and avidly binds UHRF1. Interaction with methylated LIG1 (show LIG1 ELISA Kits) promotes the recruitment of UHRF1 to DNA replication sites and is required for DNA methylation (show HELLS ELISA Kits) maintenance.
Down-regulation of UHRF1 is an important mechanism of PIM1 (show PIM1 ELISA Kits)-mediated cellular senescence.
UHRF1 gene expression levels correlates with the major pathological characteristics of transitional cell carcinoma samples and with the clinical outcome of those patients. Determination of UHRF1 gene expression could have a potential to be used as a sensitive molecular marker in patients with urinary bladder cancer.
decreased UHRF1 expression is a key initial event in the suppression of DNMT1 (show DNMT1 ELISA Kits)-mediated DNA methylation (show HELLS ELISA Kits) and in the consequent induction of senescence via increasing WNT5A (show WNT5A ELISA Kits) expression
Our results provide insights into the molecular basis of DNMT1 (show DNMT1 ELISA Kits) dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (show HELLS ELISA Kits) in pluripotent and differentiating cells
results identify UHRF1 as a novel HSP90 (show HSP90 ELISA Kits) client protein and shed light on the regulation of UHRF1 stability and function.
Down-regulation of UHRF1 by RNAi inhibited proliferation and clonogenic ability of medullobastoma cell lines with cell cycle arrest in G1/G2-phase. Cells transfected with lenti-shUHRF1 showed increased p16 expression and location shift of CDK4 (show CDK4 ELISA Kits) in medulloblastoma cells.
Our study uncovered that UHRF1 overexpressed in cervical squamous cell carcinoma and silent UHRF1 gene can reduce tumorigenicity of the CaSki cells by decreasing its proliferation capacity and making it stagnate at G0 and G1 phases as well as accelerating its apoptosis
The overexpression of UHRF1 was correlated with the stage and grade of gastric cancer and is associated with the genotype distribution of MiR (show MLXIP ELISA Kits)-146a rs2910164.
Studies indicate that ubiquitin like with PHD and ring finger domains 1 protein (UHRF1) interacts with DNA interstrand crosslinks (ICLs) both in vitro and in vivo.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 ELISA Kits), Dnmt3a (show DNMT3A ELISA Kits), Hdac1 (show HDAC1 ELISA Kits), Kdm3a (show KDM3A ELISA Kits) and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
Dnmt1 (show DNMT1 ELISA Kits) stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
DNA hypomethylation is the mechanism underlying the cell cycle block and small liver phenotype caused by uhrf1 depletion.
an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2 (show CDK2 ELISA Kits)/cyclin A2 (show CCNA2 ELISA Kits) during early vertebrate development
These data provide the first evidence that Uhrf1 and Dnmt1 (show DNMT1 ELISA Kits) function is required for vertebrate lens development and maintenance.
uhrf1 is required for physiologic liver growth in both embryos and adults
Whole genome bisulfite sequencing revealed that blastocysts derived from KO oocytes have a greatly reduced level of CG methylation, suggesting that maternal UHRF1 is essential for maintaining CG methylation, particularly at the imprinting control regions, in preimplantation embryos.
SETDB1 (show SETDB1 ELISA Kits) maintains silencing of intracisternal A particle, but in the absence of DNMT1 (show DNMT1 ELISA Kits), prolonged binding of NP95 to hemimethylated DNA transiently disrupts SETDB1 (show SETDB1 ELISA Kits)-dependent H3K9me3 deposition.
deletion of Uhrf1 lead to global DNA hypomethylation with a strong activation of the intracisternal A particle (IAP (show ALPI ELISA Kits)) family of endogenous retroviral elements, accompanied by an increase in 5-hydroxymethylcytosine
Uhrf1 regulation of the Akt (show AKT1 ELISA Kits)-mTOR (show FRAP1 ELISA Kits) signaling pathway is required for invariant natural killer T cell development.
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone (show HIST1H3B ELISA Kits) recognition.
the histone modification status at the DMRs of imprinted genes may dictate whether DNA methylation (show HELLS ELISA Kits) could be restored upon UHRF1 re-expression
UHRF1 is strongly up-regulated during liver regeneration independently of BIRC5 (show BIRC5 ELISA Kits).
report identifies PARP1 (show PARP1 ELISA Kits) as a novel modulator of two UHRF1-regulated heterochromatin-associated events: the accumulation of H4K20me3 and the clearance of DNMT1 (show DNMT1 ELISA Kits)
May act as a negative regulator of cell growth.
ubiquitin-like, containing PHD and RING finger domains, 1
, ubiquitin-like with PHD and ring finger domains 1
, E3 ubiquitin-protein ligase UHRF1
, RING finger protein 106
, inverted CCAAT box-binding protein of 90 kDa
, nuclear protein 95
, nuclear zinc finger protein Np95
, transcription factor ICBP90
, ubiquitin-like PHD and RING finger domain-containing protein 1
, ubiquitin-like-containing PHD and RING finger domains protein 1
, liver regeneration-related protein LRRG126
, ICBP90 binding protein 1
, ICBP90-binding protein 1
, UHRF1 (ICBP90) binding protein 1
, UHRF1-binding protein 1
, ubiquitin-like containing PHD and RING finger domains 1-binding protein 1