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UBA5 encodes a member of the E1-like ubiquitin-activating enzyme family. Additionally we are shipping UBA5 Antibodies (34) and many more products for this protein.
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clinical, biochemical, and experimental findings support our finding of UBA5 mutations as a pathophysiological cause for early-onset encephalopathies due to abnormal protein ufmylation
Heterozygous mutations in the UBA5 gene in two sisters with early-onset epileptic encephalopathy .
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy
study provides important structural and functional insights into the interaction between UBA5 and Ub-like modifiers, improving the understanding of the biology of the ufmylation pathway.
The study of UBA5-R246X revealed a dramatically decreased half-life and loss of UFM1 (show UFM1 Proteins) activation due to the absence of the catalytic cysteine Cys250.
Uba5 residues 364-404 were demonstrated to be necessary for the transthiolation of Ufm1 (show UFM1 Proteins) to Ufc1 (show UFC1 Proteins), and Uba5 381-404 was identified to be the minimal region for Ufc1 (show UFC1 Proteins) recognition
Crystallization of Uba5 residues 57-363 was performed at 277 K using PEG (show PAEP Proteins) 3350 as the precipitant, and crystals optimized by microseeding diffracted to 2.95 A resolution, with unit-cell parameters a=b=97.66, c=144.83 A, alpha=beta=90, gamma=120 degrees .
binding of ATP to Uba5 approximately Ufm1 (show UFM1 Proteins) thioester was required for efficient transfer of Ufm1 (show UFM1 Proteins) from Uba5 to Ufc1 (show UFC1 Proteins) via transthiolation.
Studies reveal structural features of UBA5 that further understanding of the enzyme reaction mechanism and provide insight into the evolution of ubiquitin activation.
UBE1DC1 greatly activated SUMO2 (show SUMO2 Proteins) in the nucleus or transferred activated-SUMO2 (show SUMO2 Proteins) to nucleus after it conjugated SUMO2 (show SUMO2 Proteins) in the cytoplasm.
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice.
This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has also been identified.
ubiquitin-activating enzyme E1-domain containing 1
, UFM1-activating enzyme
, Ubiquitin-activating enzyme 5
, Ubiquitin-activating enzyme E1 domain-containing protein 1
, ubiquitin-like modifier-activating enzyme 5
, ubiquitin-like modifier activating enzyme 5
, UBA5, ubiquitin-activating enzyme E1 homolog
, ubiquitin-activating enzyme 5
, ubiquitin-activating enzyme E1 domain-containing protein 1
, ubiquitin activating enzyme-like protein