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Involved in gene transcription regulation.
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UXT-V1 represents a novel integral component of the MAVS (show MAVS Antibodies) signalosome on mitochondria, mediating the innate antiviral signal transduction.
these results suggest that Als2 (show ALS2 Antibodies) is a binding partner of Uxt and Als2 (show ALS2 Antibodies)/Uxt interaction could be important for the activation of Nf-kappaB (show NFKB1 Antibodies) pathway.
Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF (show TNF Antibodies)-induced apoptosis. It protects cells against TNF (show TNF Antibodies)-induced apoptosis through modulating complex II formation.
Uxt is a novel and essential cofactor in the NF-kappa B (show NFKB1 Antibodies) transcriptional enhanceosome.
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region (By similarity).
, ubiquitously expressed transcript protein
, ubiquitously-expressed transcript