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Unc-13 Homolog D (C. Elegans) (UNC13D) ELISA Kits

UNC13D encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. Additionally we are shipping Unc-13 Homolog D (C. Elegans) Antibodies (55) and Unc-13 Homolog D (C. Elegans) Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human UNC13D UNC13D 201294 Q70J99
Anti-Mouse UNC13D UNC13D 70450 B2RUP2
Anti-Rat UNC13D UNC13D 192177 Q9R189
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More ELISA Kits for Unc-13 Homolog D (C. Elegans) Interaction Partners

Human Unc-13 Homolog D (C. Elegans) (UNC13D) interaction partners

  1. Munc13-4 conveys Ca(2 (show CA2 ELISA Kits)+) sensitivity to platelet SNARE (show NAPA ELISA Kits)-mediated membrane fusion and reveal a potential mechanism by which Munc13-4 bridges and stabilizes apposing membranes destined for fusion.

  2. Synergistic defects of UNC13D and AP3B1 (show AP3B1 ELISA Kits) leading to adult hemophagocytic lymphohistiocytosis.

  3. Data (including data from studies in knockout mice) suggest Munc13-4 binds to Rab11 and regulates trafficking of Rab11-containing vesicles; Munc13-4 appears to regulate final steps of Rab11-positive vesicle docking at plasma membrane in exocytosis.

  4. These studies highlight the need for RAB27A (show RAB27A ELISA Kits) sequencing in patients with FHL (show FHL1 ELISA Kits) with normal pigmentation and identify a critical binding site for Munc13-4 on Rab27a (show RAB27A ELISA Kits), revealing the molecular basis of this interaction.

  5. These data support an important role for Munc13-4 in human platelet degranulation

  6. Data indicate that Munc13-4 is highly expressed in differentiated NK cells and effector CD8 (show CD8A ELISA Kits)(+) T lymphocytes.

  7. this is the first report of HLH in association with EVC (show EVC ELISA Kits) syndrome, and the IVS13+5G>A mutation that we believe is causative of EVC (show EVC ELISA Kits) in our patient is also unreported.

  8. The prevalence of a 253-kb inversion and two deep intronic mutations, c.118-308C > T and c.118-307G > A, in UNC13D was determined in 1709 North American patients with type 3 hemophagocytic lymphohistiocytosis. 8 new mutations were also found.

  9. Data show that all but one patient with atypical familial hemophagocytic lymphohistiocytosis carried at least one splice-site mutation in UNC13D or STXBP2 (show STXBP2 ELISA Kits).

  10. This patient the patient carried mutations in FAS (show FAS ELISA Kits), XIAP (show XIAP ELISA Kits), and UNC13D genes inherited from his mother who had rheumatoid arthritis; UNC13D is involved in familial hemophagocytic lymphohistiocytosis

Mouse (Murine) Unc-13 Homolog D (C. Elegans) (UNC13D) interaction partners

  1. Munc13-4 is a syntaxin 7 (show STX7 ELISA Kits) binding protein and an important regulator of late endosome maturation.

  2. Munc13-4 conveys Ca(2 (show CA2 ELISA Kits)+) sensitivity to platelet SNARE (show VTI1B ELISA Kits)-mediated membrane fusion and reveal a potential mechanism by which Munc13-4 bridges and stabilizes apposing membranes destined for fusion.

  3. Data (including data from studies in knockout mice) suggest Munc13-4 binds to Rab11 and regulates trafficking of Rab11-containing vesicles; Munc13-4 appears to regulate final steps of Rab11-positive vesicle docking at plasma membrane in exocytosis.

  4. Letter: data argue for a critical role of Munc13-4 and therefore also dense granule secretion in infarct progression but not in safeguarding the brain vasculature in acute ischemia.

  5. Munc13-4 isoform is functionaly redundant in cytotoxic T lymphocytes.

  6. Data suggest that Rab27a (show RAB27A ELISA Kits) and Rab27b (show RAB27B ELISA Kits) regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (show RAB27A ELISA Kits)/Mlph (show MLPH ELISA Kits)/MyoVa (show MYO5A ELISA Kits) regulating cortical actin stability upstream of Rab27a/b (show RAB27A ELISA Kits)/Munc13-4-dependent granule exocytosis.

  7. MUNC13-4 is essential for phagosomal maturation and bacterial killing in neutrophils.

  8. data indicate that Rab27a (show RAB27A ELISA Kits) but not Munc13-4 plays an important role in neutrophil recruitment to liver and LPS (show TLR4 ELISA Kits)-induced death during endotoxemia

  9. Munc13-4 restricts motility of Rab27a (show RAB27A ELISA Kits)-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis.

  10. importance of Munc13-4 in platelets: it is a limiting factor required for platelet secretion and hemostasis

Unc-13 Homolog D (C. Elegans) (UNC13D) Antigen Profile

Antigen Summary

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

Gene names and symbols associated with UNC13D

  • munc13-4 (AaeL_AAEL004694) antibody
  • munc13-4 (AaeL_AAEL002724) antibody
  • munc13-4 (CpipJ_CPIJ003310) antibody
  • munc13-4 (CpipJ_CPIJ007008) antibody
  • unc-13 homolog D (C. elegans) (UNC13D) antibody
  • unc-13 homolog D (C. elegans) (unc13d) antibody
  • unc-13 homolog D (unc13d) antibody
  • unc-13 homolog D (un13d) antibody
  • unc-13 homolog D (C. elegans) (Unc13d) antibody
  • 2610108D09Rik antibody
  • FHL3 antibody
  • HLH3 antibody
  • HPLH3 antibody
  • Jinx antibody
  • mFLJ00067 antibody
  • Munc13-4 antibody
  • UNC13D antibody
  • Unc13h4 antibody

Protein level used designations for UNC13D

munc13-4 , unc-13 homolog D (C. elegans) , protein unc-13 homolog D , protein unc-13 homolog D-like , unc-13 homolog D , likely ortholog of H. sapiens unc-13 homolog D (UNC13D)

GENE ID SPECIES
5565257 Aedes aegypti
5575755 Aedes aegypti
6034762 Culex quinquefasciatus
6038676 Culex quinquefasciatus
417369 Gallus gallus
454891 Pan troglodytes
506146 Bos taurus
704431 Macaca mulatta
100027164 Monodelphis domestica
100059416 Equus caballus
100390869 Callithrix jacchus
100458741 Pongo abelii
100521332 Sus scrofa
100555716 Anolis carolinensis
100145635 Xenopus (Silurana) tropicalis
100194820 Salmo salar
201294 Homo sapiens
70450 Mus musculus
483319 Canis lupus familiaris
192177 Rattus norvegicus
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