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Unc-5 Homolog B (C. Elegans) Proteins (UNC5B)

UNC5B encodes a member of the netrin family of receptors. Additionally we are shipping Unc-5 Homolog B (C. Elegans) Antibodies (39) and Unc-5 Homolog B (C. Elegans) Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UNC5B 219699 Q8IZJ1
UNC5B 107449 Q8K1S3
UNC5B 60630 O08722
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Top Unc-5 Homolog B (C. Elegans) Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Human Human Fc Tag   50 μg Log in to see 5 to 8 Days
$341.25
Details
HOST_Human Cells Human ECD,Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_HEK-293 Human Fc Tag   10 μg Log in to see 2 to 3 Days
$231.00
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,951.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,955.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UNC5B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , , ,
Mouse (Murine)

Rat (Rattus) ,
,

More Proteins for Unc-5 Homolog B (C. Elegans) (UNC5B) Interaction Partners

Zebrafish Unc-5 Homolog B (C. Elegans) (UNC5B) interaction partners

  1. Disruption of the Unc5b or netrin-1a leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation

  2. UNC5B-mediated signaling is a specific and autonomous component of fetal-placental angiogenesis.

Pig (Porcine) Unc-5 Homolog B (C. Elegans) (UNC5B) interaction partners

  1. findings show that the netrin-1 (show NTN1 Proteins) and p53RDL1 system may regulate the induction of apoptosis in porcine granulosa cells

Human Unc-5 Homolog B (C. Elegans) (UNC5B) interaction partners

  1. UNC5B expression is decreased in bladder cancer cells compared to normal bladder cell lines.

  2. Data indicate that dysregulation of expression of netrin-1 NTN1 (show NTN1 Proteins) in smooth muscle cell (SMC (show DYM Proteins)) and its chemorepulsive receptor UNC5B in macrophages are involved in the development of atherosclerosis and unstable plaques.

  3. unc5b expression is greater in adipose tissue of obese versus lean subjects.

  4. Higher netrin-1 (show NTN1 Proteins) and lower UNC5B expression in all prostate carcinoma cell lines indicated that netrin-1 (show NTN1 Proteins) and UNC5B could be used to predict metastasis.

  5. Low UNC5B expression was an independent risk factor for postoperative recurrence in patients with different stages and grades bladder cancer.

  6. UNC5B protein expressed in macrophages in hypoxic regions of atherosclerotic regions in human.

  7. UNC5B was downregulated in kidney carcinoma.

  8. Reducing Unc5b levels in Sip1 knockout slices and brains rescues cell migration in cortical interneurons.

  9. Hypoxia-inducible factor 1 (show HIF1A Proteins) controls the expression of the uncoordinated-5-B receptor, but not of netrin-1 (show NTN1 Proteins), in first trimester human placenta

  10. The mRNA expression analysis using tissue samples revealed that UNC5B mRNA was down-expressed in about 20% of CRC (show CALR Proteins) patients, and the patients with low-UNC5B-expression tumors showed a significantly higher recurrence rate after curative surgery.

Mouse (Murine) Unc-5 Homolog B (C. Elegans) (UNC5B) interaction partners

  1. Data showed that albuminuria was significantly more pronounced in mice with proximal tubule specific deletion of UNC5B.

  2. UNC5B receptor deletion exacerbates DSS (show PMP22 Proteins)-induced colitis in mice by increasing epithelial cell apoptosis.

  3. unc5b expression is greater in adipose tissue of obese versus lean mice.

  4. UNC5B plays a critical role in cell survival and kidney injury through Akt (show AKT1 Proteins)-mediated inactivation of p53 (show TP53 Proteins) in response to stress.

  5. These studies demonstrate an important role for UNC5B during myocardial ischemia-reperfusion injury.

  6. a significant role for UNC5B in the development of hepatic IRI and identified UNC5B as a potential drug target to prevent liver dysfunction in the future.

  7. Robo4 (show ROBO4 Proteins) specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.

  8. Netrin-1 (show NTN1 Proteins) acting through the UNC5B receptor reduces renal ischemia-reperfusion injury and its associated renal inflammation.

  9. Unc5h2 was cloned; its mRNA is observed during early blood vessel formation, in the semicircular canal and in a dorsal to ventral gradient in the retina in developing mouse

  10. Disruption of the Unc5b gene leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation

Unc-5 Homolog B (C. Elegans) (UNC5B) Protein Profile

Protein Summary

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with UNC5B

  • unc-5 homolog B (C. elegans) (UNC5B)
  • unc-5 homolog B (C. elegans) (unc5b)
  • unc-5 homolog B (unc5b)
  • unc-5 homolog B (C. elegans) (Unc5b)
  • 6330415E02Rik protein
  • A630020F16 protein
  • D10Bwg0792e protein
  • p53rdl1 protein
  • UNC5B protein
  • UNC5C protein
  • Unc5h2 protein

Protein level used designations for UNC5B

UNC5H2 , netrin receptor UNC5B , unc-5 homolog B (C. elegans) , unc-5 homolog C , p53-regulated receptor for death and life , UNC-5 receptor , protein Xunc-5 , protein unc-5 homolog , p53-regulated receptor for death and life protein 1 , protein unc-5 homolog 2 , protein unc-5 homolog B , transmembrane receptor Unc5H2 , unc-5 homolog 2 , unc5 homolog 2

GENE ID SPECIES
423716 Gallus gallus
479239 Canis lupus familiaris
494130 Danio rerio
524942 Bos taurus
733600 Sus scrofa
715786 Macaca mulatta
100072764 Equus caballus
398393 Xenopus laevis
219699 Homo sapiens
107449 Mus musculus
60630 Rattus norvegicus
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