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anti-Unc-5 Homolog C (C. Elegans) (Unc5c) Antibodies

Unc5c product belongs to the UNC-5 family of netrin receptors. Additionally we are shipping Unc5c Proteins (7) and Unc5c Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Unc5c 8633 O95185
Unc5c 22253 O08747
Unc5c 362049 Q761X5
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Top anti-Unc5c Antibodies at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-UNC5C Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Goat Un-conjugated IF, IHC (p) 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of UNC5C Antibody (Center) (ABIN390906) in K562 ... Formalin-fixed and paraffin-embedded human brain tissue with UNC5C Ant... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Formalin-fixed and paraffin-embedded human brain tissue with UNC5C Ant... Western blot analysis of UNC5C Antibody (Center) in K562 cell line lys... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-UNC5C Antibody Titration: 0.2-1 ug/mlPositive Contro... WB Suggested Anti-UNC5C  Antibody Titration: 0.2-1 µg/mL  Positive Con... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Goat Un-conjugated IF, IHC (p), ELISA, WB 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Goat Un-conjugated IHC, ELISA, WB (50ug/ml) staining of islets in Mouse Pancreas. Citrate antigen retrie... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB UNC5C Antibody (N-term) (ABIN1881983) western blot analysis in CEM cel... 400 μL Log in to see 10 to 11 Days
$324.50
Details

Unc5c Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-Unc5c Antibodies

  1. Chicken Polyclonal Unc5c Primary Antibody for WB - ABIN2773863 : Shin, Nagasaka, Jung, Matsubara, Kim, Carethers, Boland, Goel: Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. in Gastroenterology 2007 (PubMed)

  2. Human Polyclonal Unc5c Primary Antibody for FACS, IHC (p) - ABIN390906 : Hibi, Mizukami, Shirahata, Goto, Sakata, Sanada: Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer. in World journal of surgery 2009 (PubMed)

More Antibodies against Unc5c Interaction Partners

Human Unc-5 Homolog C (C. Elegans) (Unc5c) interaction partners

  1. identify the V-2 domain of netrin-1 (show NTN1 Antibodies) to be important for its interaction with the Ig1/Ig2 domains of UNC5H2 (show UNC5B Antibodies)

  2. we have identified novel frequent somatic mutations of UNC5C in muscle-invasive bladder cancers.

  3. T835M (rs137875858) in the UNC5C wa (show CA3 Antibodies)s associated with late-onset Alzheimer disease and increased cell death in HEK293 cells.

  4. UNC5C mutations are very rare in familial and sporadic colorectal carcinomas.

  5. TNM (show ODZ1 Antibodies) stage 1 hepatocellular carcinoma (HCC (show FAM126A Antibodies)) presented UNC5C methylation, indicating that the UNC5C gene has been methylated from the early stages of HCC (show FAM126A Antibodies).

  6. knockdown of DSCAM (show DSCAM Antibodies) inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn (show FYN Antibodies) as well as the interaction of UNC5C with Fyn (show FYN Antibodies). The double knockdown of both receptors abolishes the induction of Fyn (show FYN Antibodies) tyrosine phosphorylation by netrin-1 (show NTN1 Antibodies)

  7. Inherited mutations in UNC5C prevent apoptosis and increase risk of colorectal cancer.

  8. UNC5C acts as a tumour suppressor in RCC (show XRCC1 Antibodies) and is down-regulated in RCC (show XRCC1 Antibodies). Loss of heterozygosity and DNA methylation (show HELLS Antibodies) contribute to the inactivation of UNC5C in renal cell carcinoma (show MOK Antibodies).

  9. UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.

  10. may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 (show NTN1 Antibodies) availability by inducing apoptosis

Mouse (Murine) Unc-5 Homolog C (C. Elegans) (Unc5c) interaction partners

  1. UNC5C expression levels increased from the 4-cell stage to the blastocyst stage in fertilized murine embryos. Repression of UNC5C in the anterior nucleus stage inhibited development to the blastocyst stage.

  2. UNC5c expression is enriched in CA3 (show CA3 Antibodies) hippocampal neurons, but UNC5c is not expressed in microglia or perpheral blood mononuclear cells.

  3. Unc5C and DCC (show DCC Antibodies) act downstream of Ctip2 (show BCL11B Antibodies) and Satb2 (show SATB2 Antibodies) and contribute to corpus callosum formation.

  4. unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice. This phenotype is identical to that produced by dcc (show DCC Antibodies) haploinsufficiency and is observed after adolescence.

  5. this study suggested that Unc5c plays a broad role in dorsal guidance of axons in the developing hindbrain.

  6. These results support an important role for UNC5C in spinal accessory motor neuron development.

  7. repression of Unc5c expression by Rhox5 may, in part, mediate the pro-survival function of Rhox5 in the testis

  8. The netrin-1 receptor UNC5c, a proapoptotic molecule that is inhibited by RHOX5, was also regulated in vivo, and is thus a candidate to be downstream of RHOX5 in a prosurvival germ-cell pathway.

Cow (Bovine) Unc-5 Homolog C (C. Elegans) (Unc5c) interaction partners

  1. Cows with higher conception rates carried the A+169G polymorphism in the 3' untranslated region of UNC5C (show UNC5B Antibodies), which transcripts were expressed at higher levels than those carrying the G polymorphism, which might cause poor preimplantation embryo development.

Unc5c Antigen Profile

Protein Summary

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin\; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.

Gene names and symbols associated with Unc5c

  • unc-5 homolog C (C. elegans) (UNC5C) antibody
  • unc-5 homolog C (C. elegans) (Unc5c) antibody
  • unc-5 homolog C (C. elegans) (unc5c) antibody
  • 6030473H24 antibody
  • AI047720 antibody
  • B130051O18Rik antibody
  • rcm antibody
  • UNC5C antibody
  • Unc5h3 antibody
  • wu:fb03d07 antibody

Protein level used designations for Unc5c

unc-5 homolog C (C. elegans) , netrin receptor UNC5C-like , netrin receptor UNC5C , protein unc-5 homolog 3 , protein unc-5 homolog C , unc-5 homolog 3 , unc5 (C.elegans homolog) c , UNC-5 homolog 3 , rostral cerebellar malformation protein , unc5 homolog 3 , fb03d07 , UNC5-like protein 3 , cUNC-5H3

GENE ID SPECIES
471254 Pan troglodytes
100599418 Nomascus leucogenys
705591 Macaca mulatta
100016333 Monodelphis domestica
100065541 Equus caballus
100351024 Oryctolagus cuniculus
100397357 Callithrix jacchus
100443113 Pongo abelii
8633 Homo sapiens
478485 Canis lupus familiaris
22253 Mus musculus
557316 Danio rerio
395101 Gallus gallus
533256 Bos taurus
362049 Rattus norvegicus
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