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UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR\; MIM 607311) and HSP90 (HSPCA\; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]\; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008].. Additionally we are shipping UNC45A Proteins (3) and many more products for this protein.
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There is no functional redundancy between Unc45a and Unc45b (show UNC45B Antibodies) in vivo.
The results are the first to ascribe a role for Unc45a, a putative myosin chaperone, in vertebrate development, and identify a novel mechanism by which an arteriovenous malformation can form.
Results provide novel insights into the molecular mechanisms of neurite growth and define UNC-45A as a novel and master regulator of NMII-mediated cellular processes in neurons.
UNC-45A is a crucial component in regulating human NK cell cytoskeletal dynamics via promoting the formation of actomyosin complexes.
Findings identify a novel centrosomal function for UNC45A and its role in cell proliferation and tumorigenesis.
The authors found that UNC-45A is alternatively expressed at the mRNA and protein levels as two isoforms and that the two isoforms differ only by a proline-rich 15 (show PRR15 Antibodies)-amino-acid sequence near the amino-terminus.
GCUNC-45 is a novel modulator of progesterone receptor (show PGR Antibodies) chaperoning by hsp90 (show HSP90 Antibodies).
elevated GC UNC-45 protein expression in ovarian carcinoma proliferation and metastasis.
GCUNC45 is required for the normal cellular distribution of Hsp90beta (show HSP90AB1 Antibodies), but not Hsp90alpha (show HSP90AA2 Antibodies).
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR\; MIM 607311) and HSP90 (HSPCA\; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002
unc-45 homolog A (C. elegans)
, unc-45 homolog A
, protein unc-45 homolog A
, general cell UNC45
, smooth muscle cell associated protein-1
, smooth muscle cell-associated protein 1
, stromal membrane-associated protein 1
, UNC45 homolog A