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Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability..
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Therefore, extracellular Ca(2+) influences neuronal excitability through the unc-79 homolog modifier of locomotor activity 3-UNC80-NALCN complex in a G protein-dependent fashion
in the mouse hippocampal and ventral tegmental area neurons, substance P and neurotensin activate a channel complex containing NALCN and a large previously unknown protein UNC-80
UNC80 bridges between UNC79 and the cation channel (show TRPV1 Antibodies) NALCN (show NALCN Antibodies).
Further supporting the UNC80 mutations as causative of these siblings' disorder, biallelic mutations in UNC80 have recently been described among individuals with an overlapping phenotype. This report expands the disease spectrum associated with UNC80 mutations
findings demonstrate the fundamental significance of UNC80 and basal ionic conductance to human health
UNC80 encodes a large protein that is necessary for the stability and function of NALCN and for bridging NALCN to UNC79 to form a functional complex
UNC80 functions as a scaffold for Src (show SRC Antibodies) kinases in NALCN (show NALCN Antibodies) channel function.
Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.
NALCN channel associated protein
, protein unc-80 homolog
, LOW QUALITY PROTEIN: protein unc-80 homolog
, unc-80 homolog, NALCN activator