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Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Additionally we are shipping UCP2 Kits (25) and UCP2 Proteins (8) and many more products for this protein.
Showing 10 out of 130 products:
Human Polyclonal UCP2 Primary Antibody for BCA - ABIN2666219
Pierrat, Ito, Hinz, Simonen, Erdmann, Chiesi, Heim: Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family. in European journal of biochemistry / FEBS 2000
Show all 4 references for ABIN2666219
Human Polyclonal UCP2 Primary Antibody for IF (p), IHC (p) - ABIN675428
Chuang, Lin, Huang, Chang, Liou, Chen, Chang, Chan et al.: Peroxisome proliferator-activated receptors ?/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status ... in Journal of neuroinflammation 2012
Show all 2 references for ABIN675428
except for reduced lipid peroxidation, we did not observe any significant reactive oxygen species reduction associated with increased Ucp2 activation in cold-exposed group.
Estrogens may increase mitochondrial reactive oxygen species production by repressing uncoupling proteins including UCP2.
UCP2 as a selective modulator of single channel MCU (show MCU Antibodies) dependent mitochondrial Ca2 (show CA2 Antibodies)+ inward current.
GTPBP3 (show GTPBP3 Antibodies) plays a role in the regulation of UCP2 protein through AMPK (show PRKAA1 Antibodies) signaling.
We conclude that UCP2 neither mediates palmitate-induced mitochondrial ROS (show ROS1 Antibodies) generation and the associated cell loss, nor protects against these deleterious effects. Instead, UCP2 dampens palmitoleate protection against palmitate toxicity.
UCP2 is expressed in human cumulus cells.
Higher UCP2 expression corresponded with a poorer prognosis in breast cancer patients.
Data reported here suggest that the UCP2 -866A/55Val/Ins (show INS Antibodies) haplotype is associated with an increased risk for DKD and with a lower eGFR (show EGFR Antibodies) in T2DM patients
Dissipation of the proton gradient by Ucp2 is not the only determinant of the phagocytic capacity and that anion transfer or nucleotide binding by Ucp2 is also essential for Ucp2-mediated engulfment of apoptotic cells.
ectopic overexpression of UCP2 in a HCC (show FAM126A Antibodies) cell line with low endogenous UCP2 expression, HLE (show ELANE Antibodies), significantly decreased mitochondrial superoxide induction by the anti-cancer drug GEM (show GEM Antibodies).
exogenous expression of miR133a or knockdown of UCP-2 in MCF-7/Dox cells can sensitize their reaction to the treatment of Doxorubicin
Increased expression of UCP2 significantly reduced apoptosis during the critical developmental period resulting in elevated numbers of retinal ganglion cells in the adult.
Study shows that mitochondrial location controlled by UCP2 is relevant for adaptive responses of neurons in cortical and hippocampal neurons and are relevant to perinatal hypoxia-triggered circuit adaptations
Study shows that glucose load results in mitochondrial fission and reduced reactive oxygen species in ventromedial nucleus of the hypothalamus neurons mediated by dynamin (show DNM1 Antibodies)-related peptide 1 (DRP1 (show CRMP1 Antibodies)) under the control of uncoupling protein 2 (UCP2).
UCP2 modulating role in mitochondrial calcium uptake
Blocking UCP2 expression attenuates cardiac hypertrophy induced by pressure overload
UCP2 knockout suppresses mouse skin carcinogenesis.
A newly identified functional variant (rs1626521) in UCP-3 (show UCP3 Antibodies) affects postprandial gastric functions and satiety and may contribute to weight gain and alter human mitochondrial function.
while the lack of UCP2 has no acute effect on body temperature, UCP2 may inhibit rapid improvements in defense against cold, in contrast to UCP1 (show UCP1 Antibodies), whose main function is to promote thermogenesis.
high UCP2 levels allow better utilization of fatty acid oxidation resulting in a beneficial effect on mitochondrial function in heart, postponing systemic lactic acidosis and resulting in longer lifespan in these mice.
Results suggest that hippocampal UCP2 is essential for cognitive function and the resistance to anxiety of mice, but not required for the beneficial effects of exercise
Despite patent grafts, revascularized hibernating myocardium demonstrates a submaximal response to dobutamine infusion and increased mitochondrial UCP-2 expression.
Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3 (show UCP3 Antibodies), showing that UCPs have conservation and genetic reliability.
The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 and UCP3 (show UCP3 Antibodies) expression in selected muscles.
UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 (show UCP1 Antibodies) or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI (show RNF34 Antibodies)) in Angus steers selected to have high or low RFI (show RNF34 Antibodies) is presented.
These results suggest that UCP2 play an important role of lipid and energy metabolism in mammary epithelial cells.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
mitochondrial uncoupling protein 2
, uncoupling protein 2 (mitochondrial, proton carrier)
, Mitochondrial uncoupling protein 2
, uncoupling protein 2
, UCP 2
, solute carrier family 25 member 8
, uncoupling protein 2, mitochondrial
, uncoupling protein homolog
, Uncoupling protein 2, mitochondrial