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Uncoupling Protein 2 (Mitochondrial, Proton Carrier) Proteins (UCP2)

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Additionally we are shipping UCP2 Antibodies (89) and UCP2 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UCP2 7351 P55851
UCP2 22228 P70406
UCP2 54315 P56500
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Top UCP2 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$873.40
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,030.69
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,046.42
Details

UCP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) Interaction Partners

Zebrafish Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. except for reduced lipid peroxidation, we did not observe any significant reactive oxygen species reduction associated with increased Ucp2 activation in cold-exposed group.

Human Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. Estrogens may increase mitochondrial reactive oxygen species production by repressing uncoupling proteins including UCP2.

  2. UCP2 as a selective modulator of single channel MCU (show MCU Proteins) dependent mitochondrial Ca2 (show CA2 Proteins)+ inward current.

  3. GTPBP3 (show GTPBP3 Proteins) plays a role in the regulation of UCP2 protein through AMPK (show PRKAA1 Proteins) signaling.

  4. We conclude that UCP2 neither mediates palmitate-induced mitochondrial ROS (show ROS1 Proteins) generation and the associated cell loss, nor protects against these deleterious effects. Instead, UCP2 dampens palmitoleate protection against palmitate toxicity.

  5. UCP2 is expressed in human cumulus cells.

  6. Higher UCP2 expression corresponded with a poorer prognosis in breast cancer patients.

  7. Data reported here suggest that the UCP2 -866A/55Val/Ins (show INS Proteins) haplotype is associated with an increased risk for DKD and with a lower eGFR (show EGFR Proteins) in T2DM patients

  8. Dissipation of the proton gradient by Ucp2 is not the only determinant of the phagocytic capacity and that anion transfer or nucleotide binding by Ucp2 is also essential for Ucp2-mediated engulfment of apoptotic cells.

  9. ectopic overexpression of UCP2 in a HCC (show FAM126A Proteins) cell line with low endogenous UCP2 expression, HLE (show ELANE Proteins), significantly decreased mitochondrial superoxide induction by the anti-cancer drug GEM (show GEM Proteins).

  10. exogenous expression of miR133a or knockdown of UCP-2 in MCF-7/Dox cells can sensitize their reaction to the treatment of Doxorubicin

Mouse (Murine) Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. Study shows that glucose load results in mitochondrial fission and reduced reactive oxygen species in ventromedial nucleus of the hypothalamus neurons mediated by dynamin (show DNM1 Proteins)-related peptide 1 (DRP1 (show CRMP1 Proteins)) under the control of uncoupling protein 2 (UCP2).

  2. UCP2 modulating role in mitochondrial calcium uptake

  3. Blocking UCP2 expression attenuates cardiac hypertrophy induced by pressure overload

  4. UCP2 knockout suppresses mouse skin carcinogenesis.

  5. A newly identified functional variant (rs1626521) in UCP-3 affects postprandial gastric functions and satiety and may contribute to weight gain and alter human mitochondrial function.

  6. while the lack of UCP2 has no acute effect on body temperature, UCP2 may inhibit rapid improvements in defense against cold, in contrast to UCP1 (show UCP1 Proteins), whose main function is to promote thermogenesis.

  7. high UCP2 levels allow better utilization of fatty acid oxidation resulting in a beneficial effect on mitochondrial function in heart, postponing systemic lactic acidosis and resulting in longer lifespan in these mice.

  8. Results suggest that hippocampal UCP2 is essential for cognitive function and the resistance to anxiety of mice, but not required for the beneficial effects of exercise

  9. Free fatty acid recognizes UCP2 at a peripheral site via electrostatic interaction. Flipping ionized fatty acid by UCP2 is required for UCP2-mediated H+ transport in mitochondria.

  10. long-term exposure to CT-1 (show CTF1 Proteins)-CP could lead to the alteration in the expression of sarcomeric alpha-actin (show ACTA2 Proteins), alpha-actinin (show ACTN1 Proteins) and mitochondrial UCP2.

Pig (Porcine) Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. Despite patent grafts, revascularized hibernating myocardium demonstrates a submaximal response to dobutamine infusion and increased mitochondrial UCP-2 expression.

  2. Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3, showing that UCPs have conservation and genetic reliability.

  3. The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 and UCP3 expression in selected muscles.

Cow (Bovine) Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2) interaction partners

  1. UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 (show UCP1 Proteins) or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.

  2. A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI (show RNF34 Proteins)) in Angus steers selected to have high or low RFI (show RNF34 Proteins) is presented.

  3. These results suggest that UCP2 play an important role of lipid and energy metabolism in mammary epithelial cells.

UCP2 Protein Profile

Protein Summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.

Gene names and symbols associated with UCP2

  • mitochondrial uncoupling protein 2 (PTRG_09289)
  • uncoupling protein 2 (mitochondrial, proton carrier) (UCP2)
  • mitochondrial uncoupling protein 2 (LOC100282746)
  • uncoupling protein 2 (ucp2)
  • uncoupling protein 2 (mitochondrial, proton carrier) (TEgg068n20.1)
  • uncoupling protein 2 (UCP2)
  • uncoupling protein 2 (LOC100534553)
  • uncoupling protein 2 (mitochondrial, proton carrier) (Ucp2)
  • ATUCP2 protein
  • BMIQ4 protein
  • cb74 protein
  • DKFZp470P1633 protein
  • K19M22.21 protein
  • K19M22_21 protein
  • MGC53319 protein
  • MGC75881 protein
  • Slc25a8 protein
  • ucp2 protein
  • UCPH protein
  • uncoupling protein 2 protein

Protein level used designations for UCP2

mitochondrial uncoupling protein 2 , uncoupling protein 2 (mitochondrial, proton carrier) , Mitochondrial uncoupling protein 2 , uncoupling protein 2 , UCP 2 , solute carrier family 25 member 8 , zUCP2 , UCPH , uncoupling protein 2, mitochondrial , uncoupling protein homolog , Uncoupling protein 2, mitochondrial

GENE ID SPECIES
6347579 Pyrenophora tritici-repentis Pt-1C-BFP
100173815 Pongo abelii
100282746 Zea mays
379915 Xenopus laevis
394786 Xenopus (Silurana) tropicalis
555812 Danio rerio
574198 Macaca mulatta
836014 Arabidopsis thaliana
100534553 Oreochromis niloticus
7351 Homo sapiens
22228 Mus musculus
397549 Sus scrofa
54315 Rattus norvegicus
281562 Bos taurus
403576 Canis lupus familiaris
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