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Acts as a transcriptional coactivator of ATF2.. Additionally we are shipping UTF1 Antibodies (70) and many more products for this protein.
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With a sensitivity of 100% and a specificity of 97% in the detection of central nervous system (CNS) germinomas, UTF1 serves as a new reliable alternative in the diagnostic setting of CNS germ cell tumours.
UTF1 attenuates cell proliferation and is inactivated in cervical carcinogenesis through epigenetic modification.
These findings strongly suggest that UTF1 promoter methylation profile might be a useful biomarker for cervical cancer diagnosis.
Utf1 couples the core pluripotency factors with Myc (show MYC Proteins) and PRC2 networks to promote the pluripotency and proliferation of embryonic stem cells.
role for UTF1 in differentiation of matrix cells of the shaft as well as in suprabasal keratinocytes.
Human UTF1 is a tightly DNA-associated protein with transcriptional repressor activity.
Strong UTF1 staining can be used for diagnosing embryonal carcinoma and seminoma. UTF1 expression in spermatogonia suggests its possible role in spermatogenesis and renewal of spermatogonia.
The expression pattern indicated that UTF-1 plays a possible role in spermatogonial self-renewal
IPS (show SLC27A4 Proteins) cells derived from UTF1-selection give rise to functional CMs (show Cd2ap Proteins) in vitro.
A large region of Utf1 was found to be necessary for direct interaction with N-Myc (show MYCN Proteins).
Suppression of UTF1 expression in P19 cells by RNA interference enhanced retinoic acid (RA)-induced neuronal differentiation.
Data show that UTF1 is a key chromatin component in ES cells, preventing ES cell chromatin decondensation, and aberrant gene expression; both essential for proper initiation of lineage-specific differentiation of ES cells.
These results suggest a molecular pathway by which Oct-3/4 (show POU5F1 Proteins) induces rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene.
UTF1 is a strongly chromatin-associated protein involved in the initiation of ES cell differentiation.
Acts as a transcriptional coactivator of ATF2.