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May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.. Additionally we are shipping UCMA Proteins (7) and UCMA Kits (2) and many more products for this protein.
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Report a functional promoter for grp2 gene regulated by Sox9b, Sox10 (show SOX10 Antibodies), Ets1 (show ETS1 Antibodies) and Mef2ca (show MEF2C Antibodies) as determined by in vitro assays. This was confirmed in vivo for Sox9b and Sox10 (show SOX10 Antibodies).
Knockdown of ucmaa leads to severe growth retardation and perturbance of skeletal development.
The study demonstrates the involvement of GRP (show LSM4 Antibodies) in the two major molecular processes affecting osteoarthritis: mineralization and inflammation of articular tissue.
Data suggest that novel splice variants of GRP (show LSM4 Antibodies)are expressed in cartilage and other tissues (i.e. GRP (show LSM4 Antibodies)-F5, GRP- (show LSM4 Antibodies)F6); GRP-F1 is predominant splice variant expressed in adult tissues particularly in cartilage of patients with osteoarthritis.
full exon resequencing of DNA samples from 17 chronic kidney disease patients (stage 5) and 121 healthy controls in a Swsedish population; the 138Thr > Ser (show SIGLEC1 Antibodies) polymorphism seems to be the only non-synonymous SNP found in the UCMA gene in a Swedish population
Gla-rich protein (GRP) is a new vitamin K-dependent protein that can bind calcium through Gla (show NAT8 Antibodies) residues.
The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation.
Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells
Data suggest that a novel splice variant of GRP is expressed in cartilage and other tissues (i.e. GRP-F7); GRP-F1 is predominant splice variant expressed in adult tissues.
Considering that skeletal development in Ucma-deficient mice is not significantly impaired, protein expression in adult cartilage indicates that Ucma might be involved in skeletal homeostasis and in the mechanical properties of the skeleton
Four alternative splicing variants derived from the mouse Ucma/GRP gene in chondrocytes were identified and their expression and subcellular localization during chondrogenesis was determined.
May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
upper zone of growth plate and cartilage matrix associated
, Gla-Rich Protein 2
, unique cartilage matrix-associated protein
, Gla-rich protein
, upper zone of growth plate and cartilage matrix associated protein