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URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Upregulator of Cell Proliferation Antibodies (61) and Upregulator of Cell Proliferation Kits (6) and many more products for this protein.
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miR (show MLXIP Proteins)-519 inhibited URG4 expression by directly binding to the 3'UTR of URG4. miR (show MLXIP Proteins)-519 inhibited Cyclin D1 (show CCND1 Proteins) expression and the phosphorylation level of Rb, and increased p21 (show CDKN1A Proteins) and p27 (show PAK2 Proteins) expression, confirming miR (show MLXIP Proteins)-519 blocked G1/S transition.
Findings indicate that URGCP plays an important role in promoting NSCLC cell invasion and metastasis by enhancing NF-kappaB (show NFKB1 Proteins)-activated MMP-9 (show MMP9 Proteins) expression
site-directed mutagenesis of potential SP1 (show PSG1 Proteins) binding sites diminished both DNA-protein complexes and SP1 (show PSG1 Proteins)-mediated upregulation of URG-4 promoter activity. These findings are valuable for understanding transcriptional regulation of URG4/URGCP that has a pivotal role in cancer progression.
FA caused a decrease in the expression of novel gene URG4/URGCP.
URG4 overexpression increased the resistance to cisplatin-induced apoptosis in bladder cancer.
We presented first mechanisms of TMZ and URG4/URGCP relationship in neuroblastoma (show ARHGEF16 Proteins) cells in this study. As a result, TMZ may be a novel candidate agent for treatment of neuroblastoma (show ARHGEF16 Proteins) as a single or agent or together with other therapeutic agents
This study suggests that URG4/URGCP plays an important pro-angiogenic role in HCC (show FAM126A Proteins) via a mechanism linked to activation of the NF-kappaB (show NFKB1 Proteins) pathway
URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer.
Data suggest that neuroblastoma (show ARHGEF16 Proteins) (NB) cell differentiation might associate with peroxisome proliferator-activated receptor alpha (PPARalpha (show PPARA Proteins)) and URG4/URGCP gene expression profile after retinoic acid (RA) treatment.
Rapamycin diminishes URGCP gene expression in DU145 and PC3 (show PCSK1 Proteins) cells, but increases expression in LNCaP cells.
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002
upregulator of cell proliferation
, up-regulator of cell proliferation
, Protein URG4
, up-regulated gene 4
, HBxAg up-regulated gene 4 protein homolog
, HBV X protein up-regulated gene 4 protein homolog
, HBV X protein up-regulated gene 4 protein
, HBxAg up-regulated gene 4 protein
, protein URG4