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UCN is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Additionally we are shipping Urocortin Kits (25) and many more products for this protein.
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These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 (show CRHR1 Antibodies) and CRHR2 (show CRHR2 Antibodies) and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
Results describe the distribution of urotensin I, UIIalpha and UIIbeta mRNAs in different organs and the cellular localization of the three mRNAs in the spinal cord by in situ hybridization (ISH (show ANTXR2 Antibodies)) histochemistry.
Findings identify Ucn as a potential mediator that inhibits TGFbeta1 (show TGFB1 Antibodies) oncogenic signaling in breast neoplasm.
In women with adnexal endometrioma versus teratoma (show DND1 Antibodies), the medians were 105.31 pg/mL versus 120.84 pg/mL for urocortin, 7.16 pg/mL versus 9.13 pg/mL for leptin (show LEP Antibodies) and 584.33 pg/mL versus 657.82 pg/mL for ghrelin (show GHRL Antibodies) (p > 0.05), respectively.
Ucn1 prevents the development of atherosclerosis by suppressing EC inflammatory response and proliferation, macrophage foam cell formation, and VSMC migration and proliferation
These data suggest that UVB-stimulated Ucn1 contributes to TRP1 (show PRSS1 Antibodies) production via the transcription of both Nurr-1 (show NR4A2 Antibodies) and Nur77 (show NR4A1 Antibodies). Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.
Production of CRF (show CRH Antibodies) and UCN1 in human dendritic cells is strongly augmented by commensal intestinal bacteria.
Cardioplegic arrest failed to induce cardiac myocyte overexpression of urocortin in diabetic hearts.
Urocortin expression inversely correlates with higher tumor grade and advanced tumor stage in gastric adenocarcinomas.
all neonates expressed UCN1 in the Edinger-Westphal nucleus independent of the degree of neuropathological injury.
Ucn is both an essential chondrocyte survival signal peptide and a chondroprotective agent in the presence of pro-apoptotic stimuli.
A detailed conformational model for the CRF1R-Ucn1 complex based on the many ligand-receptor interactions determined was here and eventually revealed unique features of peptide ligand binding to class B GPCRs.
it is shown that CRH (show CRH Antibodies) and UCN upregulate galectin-1 (show LGALS1 Antibodies) expression in Ishikawa cell line and macrophages and this effect is mediated through CRHR1 (show CRHR1 Antibodies).
This study aims to investigate the cellular localization of CRF (show CRH Antibodies) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
CNTF (show CNTF Antibodies) activates hypothalamic urocortin 1-expressing neurons both in vitro and in vivo.
The absence of the CB1 (show CNR1 Antibodies) receptor alters the Ucn1 mRNA and peptide levels in Edinger-Westphal nucleus neurones, concomitant with an augmented stress response and increased anxiety-like behaviour.
EWcp-Ucn1 neurons play an important role in EtOH intake, preference, and reward.
CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise
Data suggest that UCN regulates osteoclast resorption by suppressing osteoclast maturation/function via suppression of constitutively active cation channel (show TRPV1 Antibodies) (CRFR2beta (show CRHR2 Antibodies)) with properties of canonical transient receptor potential 1 (TRPC1 (show TRPC1 Antibodies)) channel.
Ucn1 gene was downregulated in 5-HTT (show SLC6A4 Antibodies) KO and upregulated in 5-HTT (show SLC6A4 Antibodies) TG mice which exhibit opposite changes in anxiety-related behavior; findings suggesti this peptide can be involved in behavioral changes observed in 5-HTT (show SLC6A4 Antibodies) mutant mice
This study provides provide evidence for leptin (show LEP Antibodies) actions that go beyond the hypothalamus and proposes that leptin (show LEP Antibodies) can directly influence the activity of the midbrain Ucn1 neurons.
The lack of brain Ucn 1 immunoreactivity at birth and the gradual postnatal increase in Ucn 1 in the perioculomotor area suggests that this peptide plays a greater behavioral role in adulthood than during the early postnatal development of an organism.
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
, urocortin, preproprotein