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UTS2 encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. Additionally we are shipping Urotensin 2 Kits (45) and Urotensin 2 Proteins (4) and many more products for this protein.
Showing 10 out of 91 products:
Human Polyclonal Urotensin 2 Primary Antibody for EIA - ABIN191512
Heller, Schepke, Neef, Woitas, Rabe, Sauerbruch: Increased urotensin II plasma levels in patients with cirrhosis and portal hypertension. in Journal of hepatology 2002
Show all 3 references for ABIN191512
Human Monoclonal Urotensin 2 Primary Antibody for EIA - ABIN181138
Watanabe, Kanome, Miyazaki, Katagiri: Human urotensin II as a link between hypertension and coronary artery disease. in Hypertension research : official journal of the Japanese Society of Hypertension 2006
Show all 2 references for ABIN181138
Used transgenic rabbits as a model to study macrophage-specific expressing human UII (hUII) and studied the role of autocrine UII in the development of atherosclerosis.
Urotensin II-increased reactive oxygen species production via the NADPH oxidase (show NOX1 Antibodies) pathway is partially associated with activation of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) cascades
provide evidence that, in glioma cells, homogeneous concentration of UII allowed translocation of Galpha13 (show GNA13 Antibodies) to the UT receptor (show UTS2R Antibodies) at the plasma membrane and increased actin stress fibers, lamellipodia formation and vinculin (show VCL Antibodies)-stained focal adhesions
enzyme-linked immunosorbent assay (ELISA) and restriction fragment length polymorphism analysis were used to evaluate plasma levels of urotensin-II and Thr21Met and Ser89Asn polymorphisms of UTS2 gene in breast cancer patients.
Urotensin II can induce the proliferation of BEL (show LHX2 Antibodies)-7402 cells via the urotensin receptor (show UTS2R Antibodies) mediated PKC (show PRRT2 Antibodies)/ERK/p38 MAPK (show MAPK1 Antibodies) signaling pathways.
Urotensin-II induces activating transcription factor 3 (ATF3 (show ATF3 Antibodies)) at both mRNA and protein levels.
The significantly high Urotensin-II levels in the knee synovial fluid of osteoarthritic patients than in non-osteoarthritic patients.
This study revealed high plasma U-II level might be accepted as a risk factor for in-stent restenosis with bare metal stent
Urotensin II seems be associated with menopausal status, and extra-nodal and lymphatic invasion in breast cancer patients.
Study suggests that soluble CD40 ligand (show CD40LG Antibodies) and urotensin II likely play a role in the pathogenesis of slow coronary flow.
Urotensin II plays a role in the pathogenesis and priming of acute liver failure by triggering an inflammatory cascade and driving the early release of TNF-alpha (show TNF Antibodies) and Il1beta (show IL1B Antibodies).
UII/UTR (show UTS2R Antibodies) system plays a role in lipopolysaccharide (LPS (show TLR4 Antibodies))/D-galactosamine (GalN (show GAL Antibodies))-induced acute liver failure.
Data suggest that aortic urotensin II (UII) is increased in diabetes-associated atherosclerosis in humans and mice; diabetes-associated plaque development is attenuated by UII/UII receptor antagonism in in vitro (human) and in vivo (mouse) settings.
It is believed that U-II is an important mediator in Systemic sclerosis.
role of urotensin II gene deletion in atherosclerosis and suggest that the use of pharmaceutical agents aimed at blocking the urotensin II pathway may provide a novel approach in the treatment of atherosclerosis.
mouse UII is expressed in a subpopulation of motoneurons in the spinal cord
In the CNS UII mRNAs are expressed in brainstem and spinal motoneurons, also expressed in the medial vestibular nucleus, locus coeruleus and the ventral medulla.
increased plasma urotensin II level stimulates oxidized low-density lipoprotein and reactive oxygen species production and macrophage foam cell formation
Elevated expression of Uts2 in skeletal muscle of diabetic mouse is reported.
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.
, prepro U-II
, urotensin II
, urocortin 2