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ERG encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. Additionally we are shipping V-Ets erythroblastosis Virus E26 Oncogene Homolog (Avian) Proteins (11) and V-Ets erythroblastosis Virus E26 Oncogene Homolog (Avian) Kits (1) and many more products for this protein.
Showing 10 out of 115 products:
Human Polyclonal ERG Primary Antibody for IHC (p), IHC - ABIN250916
Tomlins, Rhodes, Perner, Dhanasekaran, Mehra, Sun, Varambally, Cao, Tchinda, Kuefer, Lee, Montie, Shah, Pienta, Rubin, Chinnaiyan: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. in Science (New York, N.Y.) 2005
KLF2 (show KLF2 Antibodies) and ERG associate in a physical complex and the two proteins synergistically activate transcription of Flk1 (show KDR Antibodies).
loss of ERG and FLI1 (show FLI1 Antibodies) might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
Combined, these data suggest a possible pathway linking GDF5 (show GDF5 Antibodies), ERG and downstream factors in the processes of chondrocyte differentiation during articular joint formation.
Our study reveals that ERG has essential and cell autonomous roles in endothelial cell development and blood vessel maintenance.
We show that the gene expression signature specifically attributable to trisomy of Erg in the murine model is strongly correlated with gene expression changes in human Down syndrome hematopoietic cells.
Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.
ERG plays a critical role in coordinating the balance between self-renewal and differentiation of HSCs.
ERG activates the transcriptional program regulated by YAP1 (show YAP1 Antibodies) of the Hippo signaling pathway and found that prostate-specific activation of either ERG or YAP1 (show YAP1 Antibodies) in mice induces similar transcriptional changes and results in age-related prostate tumors.
ERG and APLNR (show APLNR Antibodies) are essential for endothelial homeostasis in venules in the lung and that perturbation in ERG-APLNR (show APLNR Antibodies) signaling is crucial for the development of pulmonary veno-occlusive disease.
Regulation of Erg by TGF-beta (show TGFB1 Antibodies) was confirmed in these cells.
Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.
Data show that tumors displaying TMPRSS2 (show TMPRSS2 Antibodies)-ERG fusions that retained interstitial genes were less likely to be associated with biochemical recurrence
ERG, FLI1 (show FLI1 Antibodies), TAL1 (show TAL1 Antibodies), and RUNX1 (show RUNX1 Antibodies) bind at all AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies)-occupied regulatory regions, including those of the AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies) gene itself, suggesting their involvement in regulating AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies) expression levels.
four oncogenic ETS (show ETS1 Antibodies) (ERG, ETV1 (show ETV1 Antibodies), ETV4 (show ETV4 Antibodies), and ETV5 (show ETV5 Antibodies)), and no other ETS (show ETS1 Antibodies), interact with the Ewing's sarcoma breakpoint protein, EWS (show EWSR1 Antibodies).
We demonstrate a role for inflammation-induced oxidative stress in the formation of DNA breaks leading to recurrent TMPRSS2 (show TMPRSS2 Antibodies)-ERG gene fusions. The transcriptional status and epigenetic features of the target genes influence this effect.
ERG signaling in prostate cancer is driven through PRMT5 (show PRMT5 Antibodies)-dependent methylation of the androgen receptor (show AR Antibodies).
NOTCH (show NOTCH1 Antibodies) pathway inhibition antagonizes the growth and invasion of transmembrane protease serine 2 (TMPRSS2 (show TMPRSS2 Antibodies))-transforming protein ERG (ERG) (T2E) -positive prostate cancer cells.
findings have identified critical molecular mechanisms involving ERK (show EPHB2 Antibodies)-mediated ERG activation that could be exploited for therapeutic intervention in ERG-positive prostate cancers.
Detection of Gene Rearrangements in Circulating Tumor Cells: Examples of ALK (show ALK Antibodies)-, ROS1 (show ROS1 Antibodies)-, RET (show RET Antibodies)-Rearrangements in Non-Small-Cell Lung Cancer and ERG-Rearrangements in Prostate Cancer.(
The TMPRSS2 (show TMPRSS2 Antibodies)-ERG gene fusion is the most frequently observed genetic aberration in Prostate cancer.
Loss of ERG is associated with prostate tumors.
fli1 (show FLI1 Antibodies), and etsrp (show ETV2 Antibodies), demonstrated that erg (show KCNH2 Antibodies) and fli1 (show FLI1 Antibodies) act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (show CDH5 Antibodies)
A combination of gain-of-function and loss-of-function studies suggested a redundant yet specific role for erg (show KCNH2 Antibodies) in both angioblast specification/proliferation and early angiogenesis, and a synergistic interaction with the critical ETS (show ETS1 Antibodies) factor etsrp (show ETV2 Antibodies).
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
v-ets erythroblastosis virus E26 oncogene like
, Ether-a-go-go-related gene potassium channel 1
, Potassium voltage-gated channel subfamily H member 2
, v-ets erythroblastosis virus E26 oncogene homolog (avian)
, v-ets erythroblastosis virus E26 oncogene homolog
, erg gene (erg_E)
, vascular ETS factor
, transcriptional regulator ERG
, avian erythroblastosis virus E-26 (v-ets) oncogene related
, TMPRSS2/ERG fusion
, transcriptional regulator ERG (transforming protein ERG)
, v-ets avian erythroblastosis virus E26 oncogene related
, transcriptional regulator Erg