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The protein encoded by MAF is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Additionally we are shipping V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Antibodies (115) and V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Kits (22) and many more products for this protein.
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c-Maf is a critical transcription factor regulating T-cell specialization in mice, essential for generation of both RORgammat(+) Tregs and T follicular regulatory cells, but not for adipose-resident Tregs. c-Maf is induced in Tregs by IL-6 (show IL6 Proteins) and TGF-beta (show TGFB1 Proteins).
interplay between MATalpha1, c-Myc (show MYC Proteins), and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis
MafB (show MAFB Proteins) and c-Maf have different expression patterns in macrophages, suggesting differences in function.
HERC4 (show HERC4 Proteins) mediates c-Maf ubiquitination and delays growth of multiple myeloma.
Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin (show CRYAA Proteins) both directly and indirectly via up-regulation of c-Maf.
Tec (show NR4A3 Proteins) enhances c-Maf-dependent IL-4 (show IL4 Proteins) promoter activity. This effect of Tec (show NR4A3 Proteins) is counteracted by Ptpn22 (show PTPN22 Proteins), which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity.
endogenous small-Maf factors negatively regulate beta-cell function by competing for MafA (show MAFA Proteins) binding, and thus, the inhibition of small-Maf activity can improve beta-cell function
The melanoma microenvironment contributes to skewing of CD8 (show CD8A Proteins) T cell differentiation programs, in part by TGFbeta (show TGFB1 Proteins)/IL-6 (show IL6 Proteins)-mediated induction of Maf.
Sox5 (show SOX5 Proteins) physically associates with c-Maf via the HMG (show SSRP1 Proteins) domain of Sox5 (show SOX5 Proteins) and DNA-binding domain of c-Maf, and Sox5 (show SOX5 Proteins) together with c-Maf directly activates the promoter of RORgammat in CD4 (show CD4 Proteins)(+) T cells.
KLF13 (show KLF13 Proteins) directly binds to IL-4 (show IL4 Proteins) promoter regions and synergizes with c-Maf to positively regulate IL-4 (show IL4 Proteins) expression.
we identified two heterozygous rare variants in genes that are involved in early cataract development; the novel c.809C>A; p.(Ser270Tyr) in MAF and the c.168C>G; p.(Tyr56 *) variant in CRYGD (show CRYGD Proteins), previously reported as pathogenic
UBE2O (show UBE2O Proteins) mediates c-Maf polyubiquitination and degradation, induces MM cell apoptosis, and suppresses myeloma tumor growth, which provides a novel insight in understanding myelomagenesis and UBE2O (show UBE2O Proteins) biology.
The interaction between c-Maf and RORgammat, and Blimp-1 (show PRDM1 Proteins).
Polymorphisms rs9939609 (FTO (show FTO Proteins) gene) and rs1424233 (MAF gene) were genotyped using allelic discrimination assays in a prospective multicenter cohort study; these polymorphisms did not show associations with birth weight, BMI and Ponderal Index at discharge, and weight gain, neither testing for a dominant, additive nor for a recessive model.
this study shows that genes associated with MAF-binding enhancers are suppressed in macrophages isolated from rheumatoid-arthritis patients, revealing a disease-associated signature of IFN-gamma (show IFNG Proteins)-mediated repression
Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf induction were adverse events for counteracting tumor-specific Th1 (show TH1L Proteins) generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy
These results define the role of MAF and GSK3 in the resistance of t(14;16) multiple myeloma to proteasome inhibitors.
Epidermal differentiation gene regulatory networks are controlled by MAF and MAFB (show MAFB Proteins).
Findings implicate the strong effects of ROS (show ROS1 Proteins) on multiple stem cell functions with a central role for c-Maf in stem cell senescence.
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog
, c-Maf long form
, proto-oncogene c-maf
, transcription factor Maf
, Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene
, T lymphocyte c-maf long form
, c-maf proto-oncogene
, proto-oncogene c-Maf
, transcription factor Maf-2
, Proto-oncogene c-maf