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V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) ELISA Kits

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002. Additionally we are shipping V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Antibodies (56) and V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MAFA 50928 O88713
MAFA 58975 Q64335
MAFA 389692 Q8NHW3
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More ELISA Kits for V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Interaction Partners

Mouse (Murine) V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) interaction partners

  1. These findings demonstrate that regulation of monoamine levels by Mao (show MAO ELISA Kits) activity in beta cells is pivotal for physiological insulin (show INS ELISA Kits) secretion and that loss of MaoB (show MAOB ELISA Kits) expression may contribute to the beta cell dysfunction in type 2 diabetes.

  2. is necessary for the maintenance of normal insulin (show INS ELISA Kits) levels even in embryos.

  3. endogenous small-Maf (show MAF ELISA Kits) factors negatively regulate beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf (show MAF ELISA Kits) activity can improve beta-cell function

  4. Data, including data from studies using transgenic/knockout mice, confirm the expression of Mafa and Mafb (show MAFB ELISA Kits) is specific to insulin (show INS ELISA Kits)-secreting cells of the pancreas.

  5. These results suggest that MafA regulates the postnatal proliferation of beta-cells via prolactin (show PRL ELISA Kits) signaling.

  6. This finding provides a rationale for the reciprocal expression of KLRG1 (show KLRG1 ELISA Kits) and CD103 (show ITGAE ELISA Kits) in different CD8 (show CD8A ELISA Kits)(+) T-cell subsets.

  7. results illustrate how consequential the reduction in Mafa activity is to islet beta-cell function under pathophysiological conditions.

  8. Cytotoxic KLRG1 (show KLRG1 ELISA Kits)-expressed CD8 (show CD8A ELISA Kits) effector cells and defective T regulatory cells cause murine autoimmune cholangitis.

  9. KLRG1 (show KLRG1 ELISA Kits)(+) iNKT cells coexpressing CD49d and granzyme A (show GZMA ELISA Kits) persisted for several months and displayed a potent secondary response to cognate antigen.

  10. Results not only clearly define why MafA is an essential transcriptional regulator of islet beta-cells, but also why cell maturation involves coordinated actions with MafB (show MAFB ELISA Kits).

Human V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) interaction partners

  1. These findings demonstrate that regulation of monoamine levels by Mao (show MAO ELISA Kits) activity in beta cells is pivotal for physiological insulin (show INS ELISA Kits) secretion and that loss of MaoB (show MAOB ELISA Kits) expression may contribute to the beta cell dysfunction in type 2 diabetes.

  2. MAFA (show KLRG1 ELISA Kits), MAFB (show MAFB ELISA Kits), NKX6.1 (show NKX6-1 ELISA Kits), and PDX1 (show PDX1 ELISA Kits) activity provides a gauge of islet beta cell function, with loss of MAFA (show KLRG1 ELISA Kits) (and/or MAFB (show MAFB ELISA Kits)) representing an early indicator of beta cell inactivity

  3. Loss of MAFA (show KLRG1 ELISA Kits) expression is associated with insulinoma (show RPS15 ELISA Kits).

  4. MAFA (show KLRG1 ELISA Kits) nuclear expression in pancreatic alpha and beta cells, and the percentage of alpha cells expressing PAX4 (show PAX4 ELISA Kits) are altered in patients with type 2 diabetes.

  5. under oxidative and nonoxidative conditions p38 MAPK (show MAPK14 ELISA Kits) directly binds to MafA (show KLRG1 ELISA Kits) and triggers MafA (show KLRG1 ELISA Kits) degradation via ubiquitin proteasomal pathway.

  6. Beta cell nuclear MafA (show KLRG1 ELISA Kits) is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.

  7. Combined transfection of the three transcriptional factors, PDX-1 (show PDX1 ELISA Kits), NeuroD1 (show NEUROD1 ELISA Kits), and MafA (show KLRG1 ELISA Kits), causes differentiation of bone marrow mesenchymal stem cells into insulin (show INS ELISA Kits)-producing cells

  8. Data suggest that MafA (show KLRG1 ELISA Kits) plays a novel role in the reprogramming of stem cells into pancreatic beta-progenitors, promotes the islet-like characteristics of PDMSCs, as well as functionally regulation of blood glucose levels in transplanted grafts.

  9. ATF2 (show ATF2 ELISA Kits) interacts with beta-cell-enriched transcription factors, MafA (show KLRG1 ELISA Kits), Pdx1 (show PDX1 ELISA Kits), and beta2, and activates insulin (show INS ELISA Kits) gene transcription.

  10. MafA (show KLRG1 ELISA Kits) transcription is upregulated in beta-cells acutely cultured in high glucose similar to what may occur in vivo under normoglycemic conditions.

V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) Antigen Profile

Antigen Summary

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS\; MIM 176730) (Olbrot et al., 2002

Gene names and symbols associated with MAFA

  • killer cell lectin-like receptor subfamily G, member 1 (Klrg1) antibody
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (mafa) antibody
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene A (Mafa) antibody
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA) antibody
  • v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) (Mafa) antibody
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA) antibody
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) (mafa) antibody
  • 2F1-Ag antibody
  • hMafA antibody
  • L-MAF antibody
  • MAFA antibody
  • MAFA-L antibody
  • mafl antibody
  • RGD1562627 antibody
  • RIPE3b1 antibody
  • SMaf1 antibody

Protein level used designations for MAFA

killer cell lectin-like receptor subfamily G member 1 , mast cell function-associated antigen 2F1 , mast cell function-associated antigen , v-maf musculoaponeurotic fibrosarcoma oncogene homolog A , Transcription factor MafA , leucine zipper transcription factor , v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A , pancreatic beta-cell-specific transcriptional activator , transcription factor MafA , transcription factor RIPE3b1 , Mafa homolog , V-maf musculoaponeurotic fibrosarcoma oncogene homolog A , bZIP transcription factor L-Maf , lens-specific Maf , somite Maf1 , v-maf musculoaponeurotic fibrosarcoma oncogene family, protein L

GENE ID SPECIES
50928 Mus musculus
58975 Rattus norvegicus
613050 Xenopus (Silurana) tropicalis
366949 Rattus norvegicus
389692 Homo sapiens
378435 Mus musculus
395881 Gallus gallus
100000492 Danio rerio
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