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V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Proteins (MAFA)

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS\; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008].. Additionally we are shipping V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Antibodies (53) and V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAFA 50928 O88713
Rat MAFA MAFA 58975 Q64335
MAFA 389692 Q8NHW3
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Top V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,753.67
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,762.83
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details

MAFA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) Interaction Partners

Mouse (Murine) V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) interaction partners

  1. These findings demonstrate that regulation of monoamine levels by Mao activity in beta cells is pivotal for physiological insulin (show INS Proteins) secretion and that loss of MaoB (show MAOB Proteins) expression may contribute to the beta cell dysfunction in type 2 diabetes.

  2. is necessary for the maintenance of normal insulin (show INS Proteins) levels even in embryos.

  3. endogenous small-Maf (show MAF Proteins) factors negatively regulate beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf (show MAF Proteins) activity can improve beta-cell function

  4. Data, including data from studies using transgenic/knockout mice, confirm the expression of Mafa and Mafb (show MAFB Proteins) is specific to insulin (show INS Proteins)-secreting cells of the pancreas.

  5. These results suggest that MafA regulates the postnatal proliferation of beta-cells via prolactin (show PRL Proteins) signaling.

  6. This finding provides a rationale for the reciprocal expression of KLRG1 (show KLRG1 Proteins) and CD103 (show ITGAE Proteins) in different CD8 (show CD8A Proteins)(+) T-cell subsets.

  7. results illustrate how consequential the reduction in Mafa activity is to islet beta-cell function under pathophysiological conditions.

  8. Cytotoxic KLRG1 (show KLRG1 Proteins)-expressed CD8 (show CD8A Proteins) effector cells and defective T regulatory cells cause murine autoimmune cholangitis.

  9. KLRG1 (show KLRG1 Proteins)(+) iNKT cells coexpressing CD49d and granzyme A (show GZMA Proteins) persisted for several months and displayed a potent secondary response to cognate antigen.

  10. Results not only clearly define why MafA is an essential transcriptional regulator of islet beta-cells, but also why cell maturation involves coordinated actions with MafB (show MAFB Proteins).

Human V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) interaction partners

  1. These findings demonstrate that regulation of monoamine levels by Mao activity in beta cells is pivotal for physiological insulin (show INS Proteins) secretion and that loss of MaoB (show MAOB Proteins) expression may contribute to the beta cell dysfunction in type 2 diabetes.

  2. MAFA (show KLRG1 Proteins), MAFB (show MAFB Proteins), NKX6.1 (show NKX6-1 Proteins), and PDX1 (show PDX1 Proteins) activity provides a gauge of islet beta cell function, with loss of MAFA (show KLRG1 Proteins) (and/or MAFB (show MAFB Proteins)) representing an early indicator of beta cell inactivity

  3. Loss of MAFA (show KLRG1 Proteins) expression is associated with insulinoma (show RPS15 Proteins).

  4. MAFA (show KLRG1 Proteins) nuclear expression in pancreatic alpha and beta cells, and the percentage of alpha cells expressing PAX4 (show PAX4 Proteins) are altered in patients with type 2 diabetes.

  5. under oxidative and nonoxidative conditions p38 MAPK (show MAPK14 Proteins) directly binds to MafA (show KLRG1 Proteins) and triggers MafA (show KLRG1 Proteins) degradation via ubiquitin proteasomal pathway.

  6. Beta cell nuclear MafA (show KLRG1 Proteins) is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.

  7. Combined transfection of the three transcriptional factors, PDX-1 (show PDX1 Proteins), NeuroD1 (show NEUROD1 Proteins), and MafA (show KLRG1 Proteins), causes differentiation of bone marrow mesenchymal stem cells into insulin (show INS Proteins)-producing cells

  8. Data suggest that MafA (show KLRG1 Proteins) plays a novel role in the reprogramming of stem cells into pancreatic beta-progenitors, promotes the islet-like characteristics of PDMSCs, as well as functionally regulation of blood glucose levels in transplanted grafts.

  9. ATF2 (show ATF2 Proteins) interacts with beta-cell-enriched transcription factors, MafA (show KLRG1 Proteins), Pdx1 (show PDX1 Proteins), and beta2, and activates insulin (show INS Proteins) gene transcription.

  10. MafA (show KLRG1 Proteins) transcription is upregulated in beta-cells acutely cultured in high glucose similar to what may occur in vivo under normoglycemic conditions.

V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) Protein Profile

Protein Summary

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS\; MIM 176730) (Olbrot et al., 2002

Gene names and symbols associated with MAFA

  • killer cell lectin-like receptor subfamily G, member 1 (Klrg1)
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (mafa)
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene A (Mafa)
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA)
  • v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) (Mafa)
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA)
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) (mafa)
  • 2F1-Ag protein
  • hMafA protein
  • L-MAF protein
  • MAFA protein
  • MAFA-L protein
  • mafl protein
  • RGD1562627 protein
  • RIPE3b1 protein
  • SMaf1 protein

Protein level used designations for MAFA

killer cell lectin-like receptor subfamily G member 1 , mast cell function-associated antigen 2F1 , mast cell function-associated antigen , v-maf musculoaponeurotic fibrosarcoma oncogene homolog A , Transcription factor MafA , leucine zipper transcription factor , v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A , pancreatic beta-cell-specific transcriptional activator , transcription factor MafA , transcription factor RIPE3b1 , Mafa homolog , V-maf musculoaponeurotic fibrosarcoma oncogene homolog A , bZIP transcription factor L-Maf , lens-specific Maf , somite Maf1 , v-maf musculoaponeurotic fibrosarcoma oncogene family, protein L

GENE ID SPECIES
50928 Mus musculus
58975 Rattus norvegicus
613050 Xenopus (Silurana) tropicalis
366949 Rattus norvegicus
389692 Homo sapiens
378435 Mus musculus
395881 Gallus gallus
100000492 Danio rerio
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