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VTCN1 encodes a protein belonging to the B7 costimulatory protein family. Additionally we are shipping VTCN1 Antibodies (197) and VTCN1 Kits (22) and many more products for this protein.
Showing 10 out of 31 products:
Human VTCN1 Protein expressed in HEK-293 Cells - ABIN2180624
Salceda, Tang, Kmet, Munteanu, Ghosh, Macina, Liu, Pilkington, Papkoff: The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. in Experimental cell research 2005
Show all 4 references for ABIN2180624
Human VTCN1 Protein expressed in Human Cells - ABIN2003329
Suh, Wang, Duncan, Miyazaki, Cates, Walker, Gajewska, Deenick, Dawicki, Okada, Wakeham, Itie, Watts, Ohashi, Jordana, Yoshida, Mak: Generation and characterization of B7-H4/B7S1/B7x-deficient mice. in Molecular and cellular biology 2006
Results highlight an importance of VTCN1 stabilization on cell surfaces for the restora (show APCS Proteins)tion of altered balance of immune control during T1D.
Ablation of B7-H3 (show CD276 Proteins) but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.
that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease
B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells (
The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses.
Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 (show CD8A Proteins) T cell-induced diabetes.
B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.
Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells.
Tissue-specific expression of B7x protects from CD4 (show CD4 Proteins) T cell-mediated autoimmunity.
study provided the first evidence that B7-H4 facilitated esophageal squamous cell carcinoma cell proliferation through promoting IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) positive loopback pathway activation
B7H4 antigen is a negative prognostic marker for pancreatic cancer patients and also seems to express resistance of pancreatic cancer patients to chemotherapy with gemcitabine.
B7-H3 (show CD276 Proteins) and B7-H4 are involved in esophageal squamous cell carcinoma (ESCC) progression and development and their coexpression could be valuable prognostic indicators.
study suggest that serum B7-H4 is an independent prognostic indicator for HCC (show FAM126A Proteins) and may be a promising biomarker for early diagnosis as well as disease prognosis of HCC (show FAM126A Proteins).
Data show that disrupted control of costimulation, evidenced by VTCN1 loss in both APCs (show APCS Proteins) and pancreatic islets, ultimately results in altered balance of control of immune responses.
Studied VTCN1 gene polymorphisms in susceptibility to Breast Cancer.
Data indicate that the diagnostic efficiency of V-set domain containing T cell activation inhibitor 1 (sB7-H4) combined carcinoembryonic antigen (CEA (show CEACAM5 Proteins)) was superior to either sB7-H4 or CEA (show CEACAM5 Proteins).
In human amniotic fluid stem cells, the negative co-stimulatory molecule B7H4 regulates low immunogenicity, which can provide a modest inflammatory reaction microenvironment for wound repair.
Low expression of VTCN1 inhibits the viability and metastasis of ovarian carcinoma.
B7-H4 expressed is elevated in colorectal cancer tissues than in the adjacent normal tissues. B7-H4 siRNA effectively inhibited the proliferation at 24 h and 48 h, arrested cell cycle at G0/G1, and suppressed cell invasion and migration.
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
V-set domain-containing T-cell activation inhibitor 1
, V-set domain containing T cell activation inhibitor 1
, V-set domain containing T-cell activation inhibitor 1
, immune costimulatory protein B7-H4
, t cell costimulatory molecule B7x
, B7 family member, H4
, B7 superfamily member 1
, T cell costimulatory molecule B7x
, T-cell costimulatory molecule B7x