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V-Set Domain Containing T Cell Activation Inhibitor 1 Proteins (VTCN1)

VTCN1 encodes a protein belonging to the B7 costimulatory protein family. Additionally we are shipping VTCN1 Antibodies (167) and VTCN1 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VTCN1 242122 Q7TSP5
VTCN1 79679 Q7Z7D3
VTCN1 295322 Q501W4
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Top VTCN1 Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_Escherichia coli (E. coli) Human GST tag V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 26-258), (partial) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$844.80
Details

VTCN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , , ,
, , , , ,
Rat (Rattus) ,

Top referenced VTCN1 Proteins

  1. Human VTCN1 Protein expressed in HEK-293 Cells - ABIN2180624 : Salceda, Tang, Kmet, Munteanu, Ghosh, Macina, Liu, Pilkington, Papkoff: The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. in Experimental cell research 2005 (PubMed)
    Show all 4 references for ABIN2180624

  2. Human VTCN1 Protein expressed in Human Cells - ABIN2003329 : Suh, Wang, Duncan, Miyazaki, Cates, Walker, Gajewska, Deenick, Dawicki, Okada, Wakeham, Itie, Watts, Ohashi, Jordana, Yoshida, Mak: Generation and characterization of B7-H4/B7S1/B7x-deficient mice. in Molecular and cellular biology 2006 (PubMed)

More Proteins for V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) Interaction Partners

Mouse (Murine) V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) interaction partners

  1. Results highlight an importance of VTCN1 stabilization on cell surfaces for the restora (show APCS Proteins)tion of altered balance of immune control during T1D.

  2. Ablation of B7-H3 (show CD276 Proteins) but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer

  3. B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

  4. that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease

  5. B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells (

  6. The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses.

  7. Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 (show CD8A Proteins) T cell-induced diabetes.

  8. B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.

  9. Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells.

  10. Tissue-specific expression of B7x protects from CD4 (show CD4 Proteins) T cell-mediated autoimmunity.

Human V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) interaction partners

  1. study suggest that serum B7-H4 is an independent prognostic indicator for HCC (show FAM126A Proteins) and may be a promising biomarker for early diagnosis as well as disease prognosis of HCC (show FAM126A Proteins).

  2. Data show that disrupted control of costimulation, evidenced by VTCN1 loss in both APCs (show APCS Proteins) and pancreatic islets, ultimately results in altered balance of control of immune responses.

  3. Studied VTCN1 gene polymorphisms in susceptibility to Breast Cancer.

  4. Data indicate that the diagnostic efficiency of V-set domain containing T cell activation inhibitor 1 (sB7-H4) combined carcinoembryonic antigen (CEA (show CEACAM5 Proteins)) was superior to either sB7-H4 or CEA (show CEACAM5 Proteins).

  5. In human amniotic fluid stem cells, the negative co-stimulatory molecule B7H4 regulates low immunogenicity, which can provide a modest inflammatory reaction microenvironment for wound repair.

  6. Low expression of VTCN1 inhibits the viability and metastasis of ovarian carcinoma.

  7. B7-H4 expressed is elevated in colorectal cancer tissues than in the adjacent normal tissues. B7-H4 siRNA effectively inhibited the proliferation at 24 h and 48 h, arrested cell cycle at G0/G1, and suppressed cell invasion and migration.

  8. our data suggest that the evaluation of B7-H4 expression in tissues and blood is a useful tool for predicting the progression of osteosarcoma and prognosis

  9. B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

  10. B7-H4 levels in hepatocellular carcinoma patients were significantly higher than that in healthy controls. High B7-H4 levels were correlated with tumor size, tumor invasion, tumor differentiation and tumor-node metastasis stage.

VTCN1 Protein Profile

Protein Summary

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with VTCN1

  • V-set domain containing T cell activation inhibitor 1 (vtcn1)
  • V-set domain containing T cell activation inhibitor 1 (VTCN1)
  • V-set domain containing T cell activation inhibitor 1 (Vtcn1)
  • B7-H4 protein
  • B7h.5 protein
  • B7H4 protein
  • B7S1 protein
  • B7X protein
  • BC032925 protein
  • PRO1291 protein
  • RGD1311204 protein
  • VCTN1 protein

Protein level used designations for VTCN1

V-set domain-containing T-cell activation inhibitor 1 , V-set domain containing T cell activation inhibitor 1 , V-set domain containing T-cell activation inhibitor 1 , immune costimulatory protein B7-H4 , t cell costimulatory molecule B7x , B7 family member, H4 , B7 superfamily member 1 , T cell costimulatory molecule B7x , T-cell costimulatory molecule B7x

GENE ID SPECIES
379070 Xenopus laevis
418323 Gallus gallus
469433 Pan troglodytes
493551 Xenopus (Silurana) tropicalis
242122 Mus musculus
79679 Homo sapiens
295322 Rattus norvegicus
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