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V-Set and Immunoglobulin Domain-Containing Protein 4 Proteins (VSIG4)

VSIG4 encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. Additionally we are shipping VSIG4 Antibodies (38) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VSIG4 11326 Q9Y279
VSIG4 278180  
Rat VSIG4 VSIG4 312102  
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Top VSIG4 Proteins at antibodies-online.com

Showing 9 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK-293 Cells Human Un-conjugated   10 μg Log in to see 2 to 3 Days
$168.00
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$269.50
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

VSIG4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, ,
Mouse (Murine)
,

Top referenced VSIG4 Proteins

  1. Mouse (Murine) VSIG4 Protein expressed in Human Cells - ABIN2007479 : Helmy, Katschke, Gorgani, Kljavin, Elliott, Diehl, Scales, Ghilardi, van Lookeren Campagne: CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens. in Cell 2006 (PubMed)
    Show all 5 references for ABIN2007479

  2. Human VSIG4 Protein expressed in Human Cells - ABIN2005079 : Wiesmann, Katschke, Yin, Helmy, Steffek, Fairbrother, McCallum, Embuscado, DeForge, Hass, van Lookeren Campagne: Structure of C3b in complex with CRIg gives insights into regulation of complement activation. in Nature 2006 (PubMed)
    Show all 4 references for ABIN2005079

  3. Human VSIG4 Protein expressed in HEK-293 Cells - ABIN2181925 : Vogt, Schmitz, Kurrer, Bauer, Hinton, Behnke, Gatto, Sebbel, Beerli, Sonderegger, Kopf, Saudan, Bachmann: VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. in The Journal of clinical investigation 2006 (PubMed)
    Show all 2 references for ABIN2181925

More Proteins for V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) Interaction Partners

Human V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) interaction partners

  1. Data indicate that rotein kinase calpha (show PRKACA Proteins) (PKCalpha (show PKCa Proteins)) plays a role in downregulating complement receptor Ig (CRIg coded by V-set and Ig domain-containing protein 4 VSIG4) expression.

  2. complement receptor of the immunoglobulin superfamily-L-factor H (show CFH Proteins) protects glomerular mesangial cells from complement-mediated injury and proliferative lesions

  3. we identified VSIG4 as a potential diagnostic marker of severe preeclampsia. The determination of this gene may improve the prognostic assessment of severe preeclampsia.

  4. Data indicate that massive V-set and Ig domain-containing 4 VSIG4(+) cell infiltration throughout the non-small-cell lung cancer samples.

  5. we showed that a complement receptor of the Ig superfamily (CRIg, also known as Z39Ig), a receptor for complement fragments (C3b and iC3b), was expressed on a subset of intestinal macrophages in murine and human large intestine

  6. These results suggest that T cells can opposite T cell hyporesponsiveness through dampening Z39Ig inhibitory signals from macrophages and thus maintain their anti-viral function in chronic hepatitis B.

  7. Results report the identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b.

  8. These data indicate that the macrophage Z39Ig is involved in the pathogenesis of inflammatory diseases through chemokine (show CCL1 Proteins) induction, which will promote the migration of inflammatory cells into the lesion area, and MMP-9 (show MMP9 Proteins) induction.

  9. The specific expression of VSIG4 on resting macrophages suggests that VSIG4 may be important for the maintenance of T cell unresponsiveness in healthy tissues.

  10. CRIg is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases

Mouse (Murine) V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) interaction partners

  1. The macrophage-expressed VSIG4 may act to alleviate renal tubulointerstitial injury via inhibition of T cell infiltration and secretion of inflammation related factors.

  2. complement receptor of the immunoglobulin superfamily-L-factor H (show CFH Proteins) protects glomerular mesangial cells from complement-mediated injury and proliferative lesions

  3. CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3 (show CLIC3 Proteins)-dependent manner.

  4. CRIg plays an important role in regulating virus-induced Kupffer cell death and depletion of these cells from the liver sinusoidal lumen

  5. we showed that a complement receptor of the Ig superfamily (CRIg, also known as Z39Ig), a receptor for complement fragments (C3b and iC3b), was expressed on a subset of intestinal macrophages in murine and human large intestine

  6. The interstitial inflammatory cell infiltration and tubular lesion of VSIG4(-/-); urethral obstruction operation mice were increased, with the expression of TGF-beta1 (show TGFB1 Proteins) increased and MMP-2 (show MMP2 Proteins) reduced. VSIG4 may play a role in inhibiting interstitial fibrosis.

  7. Results report the identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b.

  8. The specific expression of VSIG4 on resting macrophages suggests that VSIG4 may be important for the maintenance of T cell unresponsiveness in healthy tissues.

  9. A soluble form of complement receptor of the immunoglobulin superfamily (CRIg) reversed inflammation and bone loss in two experimental models of arthritis by inhibiting the alternative pathway of complement in the joint.

  10. Antibody blocking or gene ablation of the newly identified complement receptor CRIg, but not complement receptor 3 (CR3 (show ITGAM Proteins)), rescued DAF (show CD55 Proteins)/Crry (show CR1L Proteins)-deficient platelets from complement-dependent elimination.

VSIG4 Protein Profile

Protein Summary

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with VSIG4

  • V-set and immunoglobulin domain containing 4 (VSIG4)
  • V-set and immunoglobulin domain containing 4 (Vsig4)
  • A530061A11 protein
  • BC025105 protein
  • CRIg protein
  • DKFZp468O0322 protein
  • Z39IG protein

Protein level used designations for VSIG4

V-set and immunoglobulin domain containing 4 , V-set and immunoglobulin domain-containing protein 4 , Ig superfamily protein , complement receptor of the immunoglobulin superfamily , protein Z39Ig

GENE ID SPECIES
465677 Pan troglodytes
100171405 Pongo abelii
11326 Homo sapiens
614262 Bos taurus
278180 Mus musculus
312102 Rattus norvegicus
491925 Canis lupus familiaris
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