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VGF is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. Additionally we are shipping VGF Antibodies (93) and VGF Kits (17) and many more products for this protein.
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We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4 (show SYT4 Proteins), BAG3 (show BAG3 Proteins), APOA1 (show APOA1 Proteins), and VAV3 (show VAV3 Proteins), except for VGF protein, there was a trend between the expression of these four genes and their protein levels.
Data show that two VGF peptides (NAPP-19 and QQET-30) were identified in plasma.
Data indicate an increased number of neurosecretory protein VGF-expressing T cells in patients with Alzheimer's disease (AD) compared to aged healthy controls.
Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma (show ARHGEF16 Proteins) cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element
NERPs may be potent endogenous suppressors of glucose-dependent insulin (show INS Proteins) secretion.
DISC1 (show DISC1 Proteins) knockdown leads to a reduction of VGF in neurons.
Knock-in mice expressing human VGF were fertile, had increased body weight, whereas those with c-terminal region deletion had reduced adiposity, increased energy expenditure, and improved glucose tolerance.
We conclude that VGF contributes to survival and function of peripheral T cells
Among the 19 genes tested, VGF was found to be completely methylated in several Urothelial Cell Carcinoma cell lines
results suggest hypothalamic VGF responds to environmental demands and plays an important role in energy balance and glycemic control likely acting in the melanocortin pathway downstream of BDNF (show BDNF Proteins).
Data indicate that high-fat diet induced obese mice showed reduced plasma VGF C-terminus, NAPPE and QQET-like (ERVW) peptide.
VGF expression is regulated by DISC1 (show DISC1 Proteins) through the activation of the PI3K/AKT (show AKT1 Proteins)/CREB (show CREB1 Proteins) pathway.
This study found that VGF expression, both mRNA and protein, was increased 1 h after training in the dorsal hippocampus.
Derived from the C-terminus of VGF, endogenous TLQP-21 peptide contributes to the mechanisms of spinal neuroplasticity after inflammation and nerve injury.
VGF has a role in adrenal large dense core vesicle formation and the regulation of catecholamine levels and blood pressure
These findings reveal that NERP-2 regulates glucose-stimulated insulin (show INS Proteins) secretion by elevating intracellular calcium concentrations.
VGF is regulated by SOD1 (show SOD1 Proteins) and plays a critical role in motor neuron survival
We propose that VGF and/or VGF-derived peptides modulate sympathetic outflow pathways to regulate fat storage and energy expenditure.
Modulation of VGF levels and/or VGF signaling may consequently represent an alternative means to regulate circulating glucose levels and insulin (show INS Proteins) sensitivity.
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
VGF nerve growth factor inducible
, Neurosecretory protein VGF
, neuro-endocrine specific protein VGF
, neurosecretory protein VGF
, VGF8a protein