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Vac14 Homolog (S. Cerevisiae) Proteins (VAC14)

The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. Additionally we are shipping VAC14 Antibodies (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VAC14 55697 Q08AM6
Mouse VAC14 VAC14 234729 Q80WQ2
VAC14 307842 Q80W92
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Top VAC14 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,297.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

VAC14 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

More Proteins for Vac14 Homolog (S. Cerevisiae) (VAC14) Interaction Partners

Human Vac14 Homolog (S. Cerevisiae) (VAC14) interaction partners

  1. Rab7 GAP TBC1D15 (show TBC1D15 Proteins) with Vac14.

  2. a novel regulatory mechanism whereby ArPIKfyve enhances Sac3 (show MCM3AP Proteins) abundance by attenuating Sac3 (show MCM3AP Proteins) proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J.

  3. the PIKfyve (show PIKFYVE Proteins)-associated hVac14 protein has a major role in activating PIKfyve (show PIKFYVE Proteins) and thereby regulating PtdIns(3,5)P(2) synthesis and endomembrane homeostasis in mammalian cells

  4. describe a novel interaction between the PDZ domain of nitric oxide synthase and Vac14

  5. demonstrate a coupling between the machinery for PtdIns(3,5)P2 synthesis and turnover achieved through a physical assembly of PIKfyve (show PIKFYVE Proteins), ArPIKfyve, and Sac3 (show MCM3AP Proteins).

  6. The authors data indicate that the PAS (show PASK Proteins) complex is organized to provide optimal PIKfyve (show PIKFYVE Proteins) functionality and is maintained via ArPIKfyve homomeric and heteromeric interactions.

  7. PIKfyve (show PIKFYVE Proteins)-ArPIKfyve-Sac3 (show MCM3AP Proteins) core complex: contact sites and their consequence for Sac3 (show MCM3AP Proteins) phosphatase activity and endocytic membrane homeostasis

Mouse (Murine) Vac14 Homolog (S. Cerevisiae) (VAC14) interaction partners

  1. Thus, VAC14, PI(3,5)P(2) and/or PI(5)P play a role in controlling postsynaptic function via regulation of endocytic cycling of AMPA (show GRIA3 Proteins) receptors.

  2. a novel regulatory mechanism whereby ArPIKfyve enhances Sac3 (show FIG4 Proteins) abundance by attenuating Sac3 (show FIG4 Proteins) proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J.

  3. The data demonstrate for the first time a physical association between functionally related PIKfyve (show PIKFYVE Proteins) and ArPIKfyve in 3T3-L1 adipocytes.

  4. report the characterization of a mouse mutant lacking Vac14, a regulator of PI(3,5)P(2) synthesis

  5. The authors show that Vac14 exerts an effect as a scaffold for the PI(3,5)P2 regulatory complex by direct contact with the known regulators of PI(3,5)P2: Fig4 (show FIG4 Proteins), Fab1, Vac7 and Atg18 (show WIPI1 Proteins).

VAC14 Protein Profile

Protein Summary

The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007

Gene names and symbols associated with VAC14

  • Vac14 homolog (vac14)
  • Vac14 homolog (S. cerevisiae) (VAC14)
  • Vac14 homolog (S. cerevisiae) (Vac14)
  • AA959718 protein
  • ArPIKfyve protein
  • BC032215 protein
  • D8Wsu151e protein
  • ingls protein
  • Tax1bp2 protein
  • Trx protein

Protein level used designations for VAC14

protein VAC14 homolog , Tax1 (human T-cell leukemia virus type I) binding protein 1 , Tax1 (human T-cell leukemia virus type I) binding protein 2 , tax1-binding protein 2 , vacuole morphology 14 , vacuole 14 protein

GENE ID SPECIES
447315 Xenopus laevis
55697 Homo sapiens
234729 Mus musculus
307842 Rattus norvegicus
533202 Bos taurus
415678 Gallus gallus
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