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Vaccinia Related Kinase 1 Proteins (VRK1)

VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Additionally we are shipping Vaccinia Related Kinase 1 Antibodies (64) and Vaccinia Related Kinase 1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VRK1 7443 Q99986
Mouse VRK1 VRK1 22367 Q80X41
Rat VRK1 VRK1 362779  
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Top Vaccinia Related Kinase 1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 50 μg Log in to see 16 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$788.70
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus Human GST-His-Tag Recombinant VRK1 protein tested by SDS-PAGE gel. 0.5 µg of VRK1 protein was analyzed using SDS/PAGE followed by Western blot with an anti-GST antibody. 10 μg Log in to see 1 to 2 Days
$443.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,094.67
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,184.50
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Escherichia coli (E. coli) Human DYKDDDDK Tag   10 μg Log in to see 1 to 2 Days
$443.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details

VRK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , , ,

Top referenced Vaccinia Related Kinase 1 Proteins

  1. Human VRK1 Protein expressed in Baculovirus infected Insect Cells - ABIN3216426 : Lopez-Borges, Lazo: The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. in Oncogene 2000 (PubMed)

More Proteins for Vaccinia Related Kinase 1 (VRK1) Interaction Partners

Caenorhabditis elegans (C. elegans) Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. vrk-1 has a role in early uterine development in Caenorhabditis elegans

  2. By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.

  3. Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (show TP53 Proteins).

  4. Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.

Human Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (show FAM126A Proteins).

  2. VRK1 is a novel regulator of CBs (show CBS Proteins) dynamics and stability in cell cycle by protecting coilin (show COIL Proteins) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.

  3. VRK1 regulation of NBS1 (show NBN Proteins) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.

  4. VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (show ATM Proteins) Proteins.

  5. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (show APP Proteins)). APP (show APP Proteins) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (show APP Proteins)-dependent mechanism.

  6. VRK1 can contribute to make these tumors more resistant to DNA damage-based therapies, such as ionizing radiation or doxorubicin, which is consistent with its association to a poor prognosis in ER positive breast cancer.

  7. VRK1 deficiency disrupts nuclear envelope morphology and leads to BAF (show BANF1 Proteins) retention on mitotic chromosomes.

  8. The VRK1-p53 (show TP53 Proteins) basal complex is an early-warning system for immediate cellular responses to DNA damage.

  9. This study identification of disease-causing alleles in 3 children from 2 unrelated families with Mutations in VRK1 associated with complex motor and sensory axonal neuropathy plus microcephaly.

  10. Data from molecular dynamic simulations suggest that bivalent cations play key structural roles in stabilization of VRK1/VRK2; bivalent cations have no obvious effects on VRK3. These kinases are targets in search for antineoplastic agents. [REVIEW]

Mouse (Murine) Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (show APP Proteins)). APP (show APP Proteins) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (show APP Proteins)-dependent mechanism.

  2. Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.

  3. Protein kinase (show CDK7 Proteins) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (show TP53 Proteins)-dependent manner.

  4. reduction of VRK1 activity causes a delay in meiotic progression during oogenesis

  5. VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance

  6. Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.

  7. These findings collectively support a role of VRK1 as a novel mitotic histone H3 (show HIST3H3 Proteins) kinase in mammals.

Vaccinia Related Kinase 1 (VRK1) Protein Profile

Protein Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Gene names and symbols associated with VRK1

  • vaccinia related kinase 1 (vrk1)
  • vaccinia related kinase 1 (VRK1)
  • vaccinia related kinase 1 (LOC100340357)
  • Protein VRK-1 (vrk-1)
  • vaccinia related kinase 1 (Vrk1)
  • 51PK protein
  • MGC64390 protein
  • MGC75762 protein
  • PCH1 protein
  • PCH1A protein
  • VRK1 protein
  • wu:fe16f06 protein
  • zgc:56266 protein

Protein level used designations for VRK1

vaccinia related kinase 1 , serine/threonine-protein kinase VRK1 , serine/threonine-protein kinase VRK1-like , vaccinia virus B1R-related kinase 1 , vaccinia-related kinase 1 , serine/threonine-protein kinase 51PK

GENE ID SPECIES
380541 Xenopus laevis
394552 Xenopus (Silurana) tropicalis
423443 Gallus gallus
453148 Pan troglodytes
490848 Canis lupus familiaris
704798 Macaca mulatta
100195811 Salmo salar
100401786 Callithrix jacchus
100340357 Oryctolagus cuniculus
174004 Caenorhabditis elegans
7443 Homo sapiens
22367 Mus musculus
362779 Rattus norvegicus
618880 Bos taurus
100157930 Sus scrofa
406694 Danio rerio
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